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- 详细信息
- 技术资料
- 抗体名:
轴突导向受体蛋白3抗体
- 抗体英文名:
Anti-Robo3
- 靶点:
详见说明书
- 浓度:
1mg/1ml
- 应用范围:
WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500
- 宿主:
详见说明书
- 供应商:
上海一研
- 库存:
55
- 级别:
详见说明书
- 目录编号:
详见说明书
- 抗原来源:
Rabbit
- 保质期:
详见说明书
- 适应物种:
详见说明书
- 标记物:
详见说明书
- 克隆性:
多克隆
- 保存条件:
Store at -20 °C
- 形态:
详见说明书
- 亚型:
IgG
- 免疫原:
KLH conjugated synthetic peptide derived from human Robo3 (193-240aa)
- 规格:
0.2ml/200μg
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英文名称 Anti-Robo3
中文名称 轴突导向受体蛋白3抗体图片
别 名 HGPPS; HGPS; RB inhibiting gene 1; Rbig 1; Rbig1; Retinoblastoma inhibiting gene 1; Rig 1; Rig1; Robo 3; Robo3; Robo3 protein; ROBO3_HUMAN; Roundabout axon guidance receptor homolog 3; Roundabout homolog 3; Roundabout like protein 3; Roundabout, axon guidance receptor, homolog 3 (Drosophila); Roundabout-like protein 3.
浓 度 1mg/1ml
规 格 0.2ml/200μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep
产品类型 一抗
研究领域 肿瘤 细胞生物 神经生物学 细胞膜受体
蛋白分子量 predicted molecular weight: 146kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human Robo3 (193-240aa)
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 This gene is a member of the Roundabout (ROBO) gene family that controls neurite outgrowth, growth cone guidance, and axon fasciculation. ROBO proteins are a subfamily of the immunoglobulin transmembrane receptor superfamily. SLIT proteins 1-3, a family of secreted chemorepellants, are ligands for ROBO proteins and SLIT/ROBO interactions regulate myogenesis, leukocyte migration, kidney morphogenesis, angiogenesis, and vasculogenesis in addition to neurogenesis. This gene, ROBO3, has a putative extracellular domain with five immunoglobulin (Ig)-like loops and three fibronectin (Fn) type III motifs, a transmembrane segment, and a cytoplasmic tail with three conserved signaling motifs: CC0, CC2, and CC3 (CC for conserved cytoplasmic). Unlike other ROBO family members, ROBO3 lacks motif CC1. The ROBO3 gene regulates axonal navigation at the ventral midline of the neural tube. In mouse, loss of Robo3 results in a complete failure of commissural axons to cross the midline throughout the spinal cord and the hindbrain. Mutations ROBO3 result in horizontal gaze palsy with progressive scoliosis (HGPPS); an autosomal recessive disorder characterized by congenital absence of horizontal gaze, progressive scoliosis, and failure of the corticospinal and somatosensory axon tracts to cross the midline in the medulla. Alternative transcript variants have been described but have not been experimentally validated.
Function : Thought to be involved during neural development in axonal navigation at the ventral midline of the neural tube. In spinal chord development plays a role in guiding commissural axons probably by preventing premature sensitivity to Slit proteins thus inhibiting Slit signaling through ROBO1. Required for hindbrain axon midline crossing.
Subcellular Location : Membrane; Single-pass type I membrane protein
DISEASE : Defects in ROBO3 are a cause of familial horizontal gaze palsy with progressive scoliosis (HGPPS) [MIM:607313]. Patients show a medulla where motor and sensory projections appear uncrossed.
Similarity : Belongs to the immunoglobulin superfamily. ROBO family.
Contains 3 fibronectin type-III domains.
Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
Database links : UniProtKB/Swiss-Prot: Q96MS0.2
轴突导向受体蛋白3抗体图片储存温度:
存在于血清、组织培养上清液或腹水中的抗体在-20℃下能够长期储存。低温存放不会损伤抗体活性。抗体的工作液通常储存于4℃中。此温度下,抗体的活性能稳定数月至数年亦不损失。抗体溶液不应反复冻融,因为反复冻融将导致部分抗体失活并产生不需要的蛋白—蛋白凝聚物。抗体的凝聚能导致活性丧失。这是由于抗原结合位点的空间构象被破坏,或由于产生的不溶物被离心或过滤而除去。冷凝蛋白类的抗体不能存放于4℃。因为在4℃下此类抗体会发生沉淀。一些鼠源性IgG3亚类的抗体有此特性。如果抗体在4℃下发生沉淀,就应该存放于室温下的叠氮钠溶液中。
轴突导向受体蛋白3抗体图片的分类:
按作用对象,可将其分为抗毒素、抗菌抗体、抗病毒抗体和亲细胞抗体(能与细胞结合的免疫球蛋白,如1型变态反应中的lgE反应素抗体,能吸附在靶细胞膜上);按理化性质和生物学功能,可将其分为IgM、IgG、IgA、IgE、IgD五类;按抗体的来源,可 将其分为天然抗体和免疫抗体。抗体就是免疫球蛋白,是改变了的球蛋白分子。由特异性抗原刺激产生,抗体的产生是由于抗原侵入人体后引起各种免疫细胞相互作用,使淋巴细胞中的B细胞分化增殖而形成浆细胞,浆细胞可产生分泌抗体。
DCC结肠直肠缺失基因抗体 规格: 0.1ml MMP-13基质金属蛋白酶13抗体 规格: 0.1ml
DcR3/TR6诱捕受体3抗体 规格: 0.1ml Cadherin8钙粘附蛋白8抗体 规格: 0.2ml
E2F8转录因子E2F8抗体 规格: 0.2ml THOC2转录因子THOC2抗体 0.2ml
GoatAnti-MouseIgM/PE-Cy7PE-Cy7标记的羊抗小鼠IgM 规格: 0.1ml HCV-NS4a丙型肝炎病毒-NS4a抗体 规格: 0.1ml
plantlectinB4/IB4植物凝集素IB4 0.2ml HLX1同源异型盒基因HLX1蛋白抗体 规格: 0.2ml
MaltoseBindingProtein/MBP麦芽糖结合蛋白抗体 0.2ml KLK5激肽释放酶5抗体 规格: 0.1ml
IL-6白介素6抗体 0.1ml IGSF21免疫球蛋白超家族成员21抗体 规格: 0.2ml
ASB10含锚蛋白重复序列-细胞因子信号抑制物盒蛋白家族10抗体 0.1ml GoatAnti-rabbitIgG/PE-CY5PE-CY5标记的羊抗兔IgG 规格: 0.1ml
CD146/MCAM黑色素瘤细胞粘附分子CD146抗体 规格: 0.1ml CytochromeP4502D1细胞色素CYP2D1抗体 规格: 0.1ml
CKLF趋化素样蛋白抗体 规格: 0.2ml CyclinM2/CNNM2周期素M2抗体 规格: 0.2ml
HHEX/HMPH同源盒蛋白PRH抗体 规格: 0.1ml GDF15/MIC-1生分化因子15/巨嗜细胞抑制因子1抗体 规格: 0.1ml
轴突导向受体蛋白3抗体图片AX4配对盒同源基因4抗体 规格: 0.1ml ABHD14B水解酶结构域蛋白14B抗体 规格: 0.2mlGlycerine trioleate 甘油三油酸酯 122-32-7 20mg
Falcarindiol 法卡林二醇 55297-87-5 10mg
Ethylparaben 对羟苯甲酸乙酯 120-47-8 100mg
Dimethyl phthalate 邻苯二甲酸二甲酯 131-11-3 20mg
Dimethyl Dodecanedioate 十二烷二酸二甲酯 1731-79-9 20mg
Cortisol 可的松 50-23-7 20mg
10ul短吸头 1000支 包
芬兰彩色移液器 0.5-10ul 支
Phosphotungstic acid hydrate 磷钨酸 25g 瓶
EDTA Free acid 乙二胺四乙酸 100g 瓶
动-植物激素
Weigert苏木素染色液 2×50ml 瓶
Lincomycin hydrochloride 盐酸林可霉素 25g 瓶
DRISELASW 崩溃酶 500mg 瓶
轴突导向受体蛋白3抗体图片按理化性质和生物学功能,可将其分为IgM、IgG、IgA、IgE、IgD五类。
IgM抗体是免疫应答中首先分泌的抗体。它们在与抗原结合后启动补体的级联反应。它们还把入侵者相互连接起来,聚成一堆便于巨噬细胞的吞噬;
IgG抗体激活补体,中和多种毒素。IgG持续的时间长,是 唯一能在母亲妊娠期穿过胎盘保护胎儿的抗体。他们还从乳腺分泌进入初乳,使新生儿得 到保护;
IgA抗体进入身体的黏 膜表面,包括呼吸、消化、生殖等管道的黏膜,中和感染因子。还可以通过母乳的初乳把这种抗体输送到新生儿的消化道黏膜中,是在母乳中含量最多,最为重要的一类抗体;
IgE抗体的尾部与嗜碱细胞、肥大细胞的细胞膜结合。当抗体与抗原结合后,嗜碱细胞与肥大细胞释放组织胺一类物质促进炎症的发展。这也是引发速发型过敏反应的抗体;
IgD抗体的作用还不太清楚。它们主要出现在成熟的B淋巴细胞表面上,可能与B细胞的分化有关。(IgD于1995年从人骨髓瘤蛋白中发现,分子量为175kD,主要由扁桃体、脾等处浆细胞产生,人血清中IgD浓度为3~40μg/ml,不到血清总Ig的1%,在个体发育中合成较晚。IgD铰链区很长,且对蛋白酶水解敏感,因此IgD半衰期很短,仅2.8天。血清中IgD确切的免疫功能尚不清楚。在B细胞分化到成熟B细胞阶段,除了表达SmIgD,抗原刺激后表现为免疫耐受。成熟B细胞活化后或者活化后或者变成记忆B细胞时,SmIgD逐渐消失。
英文名称 Anti-Robo3
中文名称 轴突导向受体蛋白3抗体图片
别 名 HGPPS; HGPS; RB inhibiting gene 1; Rbig 1; Rbig1; Retinoblastoma inhibiting gene 1; Rig 1; Rig1; Robo 3; Robo3; Robo3 protein; ROBO3_HUMAN; Roundabout axon guidance receptor homolog 3; Roundabout homolog 3; Roundabout like protein 3; Roundabout, axon guidance receptor, homolog 3 (Drosophila); Roundabout-like protein 3.
浓 度 1mg/1ml
规 格 0.2ml/200μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep
产品类型 一抗
研究领域 肿瘤 细胞生物 神经生物学 细胞膜受体
蛋白分子量 predicted molecular weight: 146kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human Robo3 (193-240aa)
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 This gene is a member of the Roundabout (ROBO) gene family that controls neurite outgrowth, growth cone guidance, and axon fasciculation. ROBO proteins are a subfamily of the immunoglobulin transmembrane receptor superfamily. SLIT proteins 1-3, a family of secreted chemorepellants, are ligands for ROBO proteins and SLIT/ROBO interactions regulate myogenesis, leukocyte migration, kidney morphogenesis, angiogenesis, and vasculogenesis in addition to neurogenesis. This gene, ROBO3, has a putative extracellular domain with five immunoglobulin (Ig)-like loops and three fibronectin (Fn) type III motifs, a transmembrane segment, and a cytoplasmic tail with three conserved signaling motifs: CC0, CC2, and CC3 (CC for conserved cytoplasmic). Unlike other ROBO family members, ROBO3 lacks motif CC1. The ROBO3 gene regulates axonal navigation at the ventral midline of the neural tube. In mouse, loss of Robo3 results in a complete failure of commissural axons to cross the midline throughout the spinal cord and the hindbrain. Mutations ROBO3 result in horizontal gaze palsy with progressive scoliosis (HGPPS); an autosomal recessive disorder characterized by congenital absence of horizontal gaze, progressive scoliosis, and failure of the corticospinal and somatosensory axon tracts to cross the midline in the medulla. Alternative transcript variants have been described but have not been experimentally validated.
Function : Thought to be involved during neural development in axonal navigation at the ventral midline of the neural tube. In spinal chord development plays a role in guiding commissural axons probably by preventing premature sensitivity to Slit proteins thus inhibiting Slit signaling through ROBO1. Required for hindbrain axon midline crossing.
Subcellular Location : Membrane; Single-pass type I membrane protein
DISEASE : Defects in ROBO3 are a cause of familial horizontal gaze palsy with progressive scoliosis (HGPPS) [MIM:607313]. Patients show a medulla where motor and sensory projections appear uncrossed.
Similarity : Belongs to the immunoglobulin superfamily. ROBO family.
Contains 3 fibronectin type-III domains.
Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
Database links : UniProtKB/Swiss-Prot: Q96MS0.2
轴突导向受体蛋白3抗体图片储存温度:
存在于血清、组织培养上清液或腹水中的抗体在-20℃下能够长期储存。低温存放不会损伤抗体活性。抗体的工作液通常储存于4℃中。此温度下,抗体的活性能稳定数月至数年亦不损失。抗体溶液不应反复冻融,因为反复冻融将导致部分抗体失活并产生不需要的蛋白—蛋白凝聚物。抗体的凝聚能导致活性丧失。这是由于抗原结合位点的空间构象被破坏,或由于产生的不溶物被离心或过滤而除去。冷凝蛋白类的抗体不能存放于4℃。因为在4℃下此类抗体会发生沉淀。一些鼠源性IgG3亚类的抗体有此特性。如果抗体在4℃下发生沉淀,就应该存放于室温下的叠氮钠溶液中。
轴突导向受体蛋白3抗体图片的分类:
按作用对象,可将其分为抗毒素、抗菌抗体、抗病毒抗体和亲细胞抗体(能与细胞结合的免疫球蛋白,如1型变态反应中的lgE反应素抗体,能吸附在靶细胞膜上);按理化性质和生物学功能,可将其分为IgM、IgG、IgA、IgE、IgD五类;按抗体的来源,可 将其分为天然抗体和免疫抗体。抗体就是免疫球蛋白,是改变了的球蛋白分子。由特异性抗原刺激产生,抗体的产生是由于抗原侵入人体后引起各种免疫细胞相互作用,使淋巴细胞中的B细胞分化增殖而形成浆细胞,浆细胞可产生分泌抗体。
DCC结肠直肠缺失基因抗体 规格: 0.1ml MMP-13基质金属蛋白酶13抗体 规格: 0.1ml
DcR3/TR6诱捕受体3抗体 规格: 0.1ml Cadherin8钙粘附蛋白8抗体 规格: 0.2ml
E2F8转录因子E2F8抗体 规格: 0.2ml THOC2转录因子THOC2抗体 0.2ml
GoatAnti-MouseIgM/PE-Cy7PE-Cy7标记的羊抗小鼠IgM 规格: 0.1ml HCV-NS4a丙型肝炎病毒-NS4a抗体 规格: 0.1ml
plantlectinB4/IB4植物凝集素IB4 0.2ml HLX1同源异型盒基因HLX1蛋白抗体 规格: 0.2ml
MaltoseBindingProtein/MBP麦芽糖结合蛋白抗体 0.2ml KLK5激肽释放酶5抗体 规格: 0.1ml
IL-6白介素6抗体 0.1ml IGSF21免疫球蛋白超家族成员21抗体 规格: 0.2ml
ASB10含锚蛋白重复序列-细胞因子信号抑制物盒蛋白家族10抗体 0.1ml GoatAnti-rabbitIgG/PE-CY5PE-CY5标记的羊抗兔IgG 规格: 0.1ml
CD146/MCAM黑色素瘤细胞粘附分子CD146抗体 规格: 0.1ml CytochromeP4502D1细胞色素CYP2D1抗体 规格: 0.1ml
CKLF趋化素样蛋白抗体 规格: 0.2ml CyclinM2/CNNM2周期素M2抗体 规格: 0.2ml
HHEX/HMPH同源盒蛋白PRH抗体 规格: 0.1ml GDF15/MIC-1生分化因子15/巨嗜细胞抑制因子1抗体 规格: 0.1ml
轴突导向受体蛋白3抗体图片AX4配对盒同源基因4抗体 规格: 0.1ml ABHD14B水解酶结构域蛋白14B抗体 规格: 0.2mlGlycerine trioleate 甘油三油酸酯 122-32-7 20mg
Falcarindiol 法卡林二醇 55297-87-5 10mg
Ethylparaben 对羟苯甲酸乙酯 120-47-8 100mg
Dimethyl phthalate 邻苯二甲酸二甲酯 131-11-3 20mg
Dimethyl Dodecanedioate 十二烷二酸二甲酯 1731-79-9 20mg
Cortisol 可的松 50-23-7 20mg
10ul短吸头 1000支 包
芬兰彩色移液器 0.5-10ul 支
Phosphotungstic acid hydrate 磷钨酸 25g 瓶
EDTA Free acid 乙二胺四乙酸 100g 瓶
动-植物激素
Weigert苏木素染色液 2×50ml 瓶
Lincomycin hydrochloride 盐酸林可霉素 25g 瓶
DRISELASW 崩溃酶 500mg 瓶
轴突导向受体蛋白3抗体图片按理化性质和生物学功能,可将其分为IgM、IgG、IgA、IgE、IgD五类。
IgM抗体是免疫应答中首先分泌的抗体。它们在与抗原结合后启动补体的级联反应。它们还把入侵者相互连接起来,聚成一堆便于巨噬细胞的吞噬;
IgG抗体激活补体,中和多种毒素。IgG持续的时间长,是 唯一能在母亲妊娠期穿过胎盘保护胎儿的抗体。他们还从乳腺分泌进入初乳,使新生儿得 到保护;
IgA抗体进入身体的黏 膜表面,包括呼吸、消化、生殖等管道的黏膜,中和感染因子。还可以通过母乳的初乳把这种抗体输送到新生儿的消化道黏膜中,是在母乳中含量最多,最为重要的一类抗体;
IgE抗体的尾部与嗜碱细胞、肥大细胞的细胞膜结合。当抗体与抗原结合后,嗜碱细胞与肥大细胞释放组织胺一类物质促进炎症的发展。这也是引发速发型过敏反应的抗体;
IgD抗体的作用还不太清楚。它们主要出现在成熟的B淋巴细胞表面上,可能与B细胞的分化有关。(IgD于1995年从人骨髓瘤蛋白中发现,分子量为175kD,主要由扁桃体、脾等处浆细胞产生,人血清中IgD浓度为3~40μg/ml,不到血清总Ig的1%,在个体发育中合成较晚。IgD铰链区很长,且对蛋白酶水解敏感,因此IgD半衰期很短,仅2.8天。血清中IgD确切的免疫功能尚不清楚。在B细胞分化到成熟B细胞阶段,除了表达SmIgD,抗原刺激后表现为免疫耐受。成熟B细胞活化后或者活化后或者变成记忆B细胞时,SmIgD逐渐消失。
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轴突导向受体蛋白3抗体图片
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