属性
产品名称:马来酸氯苯那敏113-92-8 敏感性:对光敏感
熔点:130-135°
溶解性:Solubility: Soluble in water
分子式 C16H19ClN2.C4H4O4
分子量390.86
描述
产品介绍:Chlorpheniramine Maleate是一种组胺H1受体拮抗剂,IC50为12 nM。
别名:马来酸氯苯那敏;扑尔敏;氯屈米通;马来那敏;Chlorphenamine maleate; Piriton;Puermin; Chlortrimeton
马来酸氯苯那敏113-92-8生化机理:Chlorpheniramine Maleate is a small molecule H1-receptor antagonist. Increased ornithine decarboxylase activity induced in an ischemia-reperfusion state was attenuated by Chlorpheniramine Maleate, indicating that this increase is mediated through engagement of the H1-receptor by histamine. Histamine-mediated repair of intestinal mucosa following ischemia-reperfusion was also demonstrated to operate through the H1-receptor with Chlorpheniramine Maleate. Induction of ornithine decarboxylase was blocked by Chlorpheniramine Maleate in Ehrlich carcinoma and MCF-7 cells. The positive inotropic effect of H1-receptor stimulation by histamine on protein tyrosine phosphorylation in guinea pig left atrium was antagonized by Chlorpheniramine Maleate.
备注:Chlorpheniramine (Chlorpheniramine maleate, Chlorphenamine) is an histamine H1 receptor antagonist with IC50 of 12 nM.
应用:An antagonist of the histamine H1-receptor.
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