Shiga Like Toxin 2B Antibody

Shiga Like Toxin 2B Antibody

CATALOGUE NUMBER

ANT-661

INTRODUCTION

Shiga-like toxin (verotoxin) is a toxin produced by some strains of Escherichia coli. Shiga-like toxin is named for its similarity to the AB5-type Shiga toxin produced by the bacteria Shigella dysenteriae. There are two known types-SLT1 and SLT2. The Shiga-like toxin is linked with hemolytic-uremic syndrome. Shiga-like toxin requires highly specific receptors on the cells'' surface in order to attach and enter the cell. Species such as cattle, swine, and deer which do not carry these receptors may harbor toxigenic bacteria without any ill effect, dropping them in their feces, from where they may be distributed to humans. Shiga Like Toxin-1 Subunit B has nontoxic action, it is the functional region which binds to the receptor. The Shiga Like Toxin-1 Subunit B can be useful in vaccine study, antibody test and other functional research.

TYPE

Mouse antibody Monoclonal.

DESCRIPTION

Shiga like toxin 2B monoclonal antibody IgG & IgG2B derived from mouse, immunized with recombinant Shiga-like toxin 2 subunit B ( E. coli O157:H7). The subunit B has nontoxic action and is a functional region which binds to the receptor. Shiga-like toxin 2 subunit B contains full amino acid sequence and forms pentamer binding to the host cell receptor.

PURIFICATION METHOD

Purified monoclonal IgG by protein A chromatography.

PURITY

Greater than 95%.

PHYSICAL APPEARANCE

Sterile Filtered clear colorless solution.

FORMULATION

1x PBS pH-7.4 + 0.05% sodium azide.

STABILITY

Shiga like toxin 2B monoclonal antibody although stable at 4°C for 1 week, should be stored below -18°C. 
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). 
Please prevent freeze-thaw cycles.

USAGE

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.