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- STX-002
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- 2025年07月12日
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- 详细信息
- 文献和实验
- 技术资料
- 库存：
大量
- 英文名：
Shiga Like Toxin-2 Subunit B Recombinant
- 保质期：
1年
- 供应商：
上海沪震实业有限公司
- 保存条件：
-20°C
- 规格：
100μg/500μg/1000μg
CATALOGUE NUMBER
STX-002
INTRODUCTION
Shiga-like toxin (verotoxin) is a toxin produced by some strains of Escherichia coli. Shiga-like toxin is named for its similarity to the AB5-type Shiga toxin produced by the bacteria Shigella dysenteriae. There are two known types-SLT1 and SLT2. The Shiga-like toxin is linked with hemolytic-uremic syndrome. Shiga-like toxin requires highly specific receptors on the cells' surface in order to attach and enter the cell. Species such as cattle, swine, and deer which do not carry these receptors may harbor toxigenic bacteria without any ill effect, dropping them in their feces, from where they may be distributed to humans. Shiga Like Toxin-2 Subunit B has nontoxic action, it is the functional region which binds to the receptor. Upon binding to the host cell receptor, the Shiga Like Toxin-2 Subunit B forms a pentamer. The Shiga Like Toxin-2 Subunit B can be useful in vaccine study, antibody test and other functional research.DESCRIPTION
Recombinant Shiga Like Toxin-2 Subunit B from E.Coli O157:H7 produced in E.coli having an Mw of 22kDa.The Shiga Like Toxin 2 protein is fused to a 6xHis tag at its N-terminus and purified by proprietary chromatographic technique.
SOURCE
Escherichia Coli.PURIFICATION METHOD
Purified by affinity chromatographic technique.
PURITY
Protein is >95% pure as determined by 12% PAGE (coomassie staining).FORMULATION
Shiga Like Toxin 2 protein solution contains PBS, 50mM arginine and 0.05% sodium azide.STABILITY
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
USAGE
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验Methods for the Purification of Shiga Toxin 1
In addition to its involvement in clinical disease, Shiga toxin (Stx) is being appreciated as a useful tool in various aspects of cell physiology. These include defining signal transduction pathways (1 –5 ), intracellular monitors
Interaction of Shiga Toxin with Endothelial Cells
The vascular endothelium was initially viewed as a “semipermeable” barrier between circulating blood and the interstitium and organ parenchyma. It is now evident that the endothelium plays a much more complex and active physiological
Shiga Toxin Interactions with the Intestinal Epithelium
in patients infected with Shiga toxin-producing E. coli (STEC). Although the majority of STEC infected patients have non-life-threatening diarrhea, STEC infection can result in serious gastrointestinal and systemic complications such as hemorrhagic colitis
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