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- prospecbio
- PKA-340
- 以色列
- 2025年07月11日
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- 详细信息
- 文献和实验
- 技术资料
- 库存：
大量
- 英文名：
c-erbB2 Protein Human Recombinant
- 保质期：
1年
- 供应商：
上海沪震实业有限公司
- 保存条件：
-20°C
- 规格：
2μg/5μg/10μg
CATALOGUE NUMBER
PKA-340
SYNONYMS
Receptor tyrosine-protein kinase erbB-2, EC 2.7.10.1, p185erbB2, C-erbB-2, NEU proto-oncogene, Tyrosine kinase-type cell surface receptor HER2, MLN 19, CD340 antigen, NEU, NGL, HER2, TKR1, HER-2, c-erb B2, HER-2/neu.INTRODUCTION
c-erbB-2 is a receptor tyrosine kinase of the c-erbB family. It is closely related instructure to the epidermal growth factor receptor. c-erbB-2 oncoprotein is detectable in a proportion of breast and other adenocarconomas, as well as transitional cell carcinomas. In the case of breast cancer, expression determined by immunohistochemistry has been shown to be associated with poor prognosis.DESCRIPTION
c-erbB-2 Human Recombinant encoding 537-636 amino acids expressed in E.coli, shows a 37kDa band on SDS-PAGE.c-erbB-2 is purified by proprietary chromatographic techniques.
SOURCE
Escherichia Coli.PHYSICAL APPEARANCE
Sterile Filtered clear solution.FORMULATION
c-erbB2 at 100 µg/ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol.STABILITY
Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.Please avoid freeze-thaw cycles.
USAGE
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验c-erbB 编码 EGF 受体，是一种分子量为 65KDa 的跨膜蛋白，由 1186 个氨基酸组成。膜外的部分（ 621aa ）是 EGF 结合功能区。前面有 24aa 构成的信号肽。跨膜区由 23 个疏水氨基酸组成。膜内部分由 542aa 组成。其中包括 4 个磷酸化位点和一个 TPK 功能区。 4 个磷酸化位点中有一个是紧靠膜内侧的 654 位 Thr ，其余 3 个位于 1068 ， 1148 和 1173Tyr 自身磷酸化位点
Overexpression of erbB- 2 is important in the pathogenesis of a variety of human neoplasms. Overexpression of the erbB- 2 gene product has been associated with poor clinical prognosis with respect to malignancies originating in the ovary
Gene Amplification of c-erbB-2 Detected by FISH
In 1981, a novel transforming gene called neu, related to, but distinct from, the c-erbB protooncogene, was identified (1 -3 ). In 1985, two groups independently isolated identical erbB -related genes from human DNA that they called HER-2
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