• 我要登录|
  • 免费注册
    |
  • 我的丁香通
    • 企业机构:
    • 成为企业机构
    • 个人用户:
    • 个人中心
  • 移动端
    移动端
丁香通 logo丁香实验_LOGO
搜实验

    大家都在搜

      大家都在搜

        0 人通过求购买到了急需的产品
        免费发布求购
        发布求购
        点赞
        收藏
        wx-share
        分享

        Gene Amplification of c-erbB-2 Detected by FISH

        互联网

        1031
        In 1981, a novel transforming gene called neu, related to, but distinct from, the c-erbB protooncogene, was identified (1 -3 ). In 1985, two groups independently isolated identical erbB -related genes from human DNA that they called HER-2 (4 ) and c-erbB-2 (5 ) located at chromosome band 17q11.2 and encoding a 185,000 Dalton tyrosine kinase (2 ,4 ). Studies conducted on human breast cancers showed 28% to have amplified HER2/neu present (7 ) and it was suggested that amplification or increased protein expression might confer a selective advantage (6 ). Over the last ten years, many studies have confirmed the value of using overexpression or amplification of the HER2/neu gene as a predictor of poor outcome in cases of breast cancer (7 -9 ). Clinical trials are currently underway using anti-HER2/neu in an attempt to destroy malignant breast cells (10 ,11 ).
        ad image
        提问
        扫一扫
        丁香实验小程序二维码
        实验小助手
        丁香实验公众号二维码
        扫码领资料
        反馈
        TOP
        打开小程序