- $1585
- Alomone
- 以色列
- AK-470
- 2025年07月12日
- 见官方网站
- 见说明书
- 见官方网站
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
见官方网站
- 亚型：
见官方网站
- 形态：
液体或冻干粉
- 保存条件：
-20°C
- 克隆性：
多克隆
- 标记物：
见官方网站
- 适应物种：
见官方网站
- 保质期：
6个月
- 抗原来源：
见说明书
- 目录编号：
AK-470
- 级别：
高
- 库存：
大量
- 供应商：
上海信裕生物科技有限公司
- 宿主：
见说明书
- 应用范围：
见官方网站
- 浓度：
见官方网站
- 靶点：
见官方网站
- 抗体英文名：
pH-Sensitive KV Channel Antibody Explorer Kit
- 抗体名：
pH-Sensitive KV Channel Antibody Explorer Kit
- 规格：
20 Vials
pH-Sensitive KV Channel Antibody Explorer Kit
A Screening Package of pH-Sensitive KV Channel Antibodies Economically PricedCat #: AK-470
20 Vials
Alomone Labs is pleased to offer the pH-Sensitive KV Channel Antibody Explorer Kit (#AK-470). The Explorer Kit contains pH-sensitive KV channel antibodies, ideal for screening purposes.
- Compounds
- Scientific Background
KV1.2 and KV1.5 are pH sensitive. KV1.5 currents are highly sensitive to acidic pH and decrease in amplitude by 46% at pH 6.3 and 96% at pH 5.3 when compared to current amplitude at pH 7.3. In contrary, KV1.2 current amplitudes are relatively insensitive to an increase in proton concentration and only decrease by 3% at pH 6.3 and 17% at pH 5.3 when compared to currents at pH 7.3. Alkaline pH slightly increases KV1.5 current amplitudes but does not seem to affect KV1.2 current amplitudes. It is hypothesized that the reduction of KV1.5 currents at pH 6.3 is caused by the accumulation of KV1.5 wild-type channels in the C-type inactivated state. External acidification slows the recovery of KV1.5 channels from inactivation by shifting the voltage dependence of activation of KV1.5 to more depolarized voltages and increasing the time required to reach maximum current amplitude in response to depolarization. External acidification has little apparent effect on the rate of KV1.2 recovery from inactivation.
The KV1.3 channel is also pH-sensitive and its properties are altered by acidic pH. Current amplitude and magnitude of inactivation of KV1.3 is reduced by acidic extracellular pH, an affect hypothesized to be induced by protonation of a histidine residue located near the channel’s pore1.
Other KV channels like KV1.4 and KV11.1 are also known to be pH-sensitive.
References
- Steidl, J.V. and Yool, A.J. (1999) Mol. Pharmacol. 55, 812.
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文献和实验All-in-One Kit for Immunohistochemical Staining for Tissues with Antibodies
of your primary antibody. 1) Heat Induced Epitope Retrieval Protocol 2) Based on the reagent that you are using, dilute the reagent to 1X as follows: To 25 ml 20×Citrate Buffer, pH 6.0 solution, add 475 ml distilled water
samples, MPC-15 for 1–15 ml samples and MPC-50 for 15–50 ml samples. Mixer allowing both tilting and rotation. Buffer 1: PBS (without Ca2 and Mg2 ) w/0.1% BSA and 2 mM EDTA, pH 7.4. Buffer 2: PBS pH 7.4 (without Ca2 and Mg2 ).
RAT/MOUSE GROWTH HORMONE ELISA KIT
polyclonal antibodies, 2) wash away of unbound materials from samples, 3) binding of a second biotinylated anti-Growth Hormone polyclonal antibody to the captured molecules, 4) wash away of unbound materials from samples, 5) conjugation of horseradish
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