- $1110
- Alomone
- 以色列
- AK-475
- 2025年07月01日
- 见官方网站
- 见说明书
- 见官方网站
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
见官方网站
- 亚型：
见官方网站
- 形态：
液体或冻干粉
- 保存条件：
-20°C
- 克隆性：
多克隆
- 标记物：
见官方网站
- 适应物种：
见官方网站
- 保质期：
6个月
- 抗原来源：
见说明书
- 目录编号：
AK-475
- 级别：
高
- 库存：
大量
- 供应商：
上海信裕生物科技有限公司
- 宿主：
见说明书
- 应用范围：
见官方网站
- 浓度：
见官方网站
- 靶点：
见官方网站
- 抗体英文名：
pH-Sensitive TRP Channel Antibody Explorer Kit
- 抗体名：
pH-Sensitive TRP Channel Antibody Explorer Kit
- 规格：
14 Vials
pH-Sensitive TRP Channel Antibody Explorer Kit
A Screening Package of pH-Sensitive TRP Channel Antibodies Economically PricedCat #: AK-475
14 Vials
Alomone Labs is pleased to offer the pH-Sensitive TRP Channel Antibody Explorer Kit (#AK-475). The Explorer Kit contains pH-sensitive TRP channel antibodies, ideal for screening purposes.
- Compounds
- Scientific Background
Transient receptor potential (TRP) channels consist of 6 transmembrane domains with a pore domain between transmembrane domains 5 and 6 and with both the C- and N-termini located intracellularly. There are five members of this family which are sensitive to pH changes.
The conductance of protons through TRPV1 results in intracellular acidification, which in turn acts on other membrane channels that are sensitive to changes in intracellular pH. TRPV1 allows a sustained inward proton current only if the extracellular pH is below 6. When sensing acidotic conditions the temperature threshold for channel activation is lowered thus enabling it to function under normal body temperature.
Similar to TRPV1, TRPV4 opens when extracellular pH drops below 6 and the channel reaches its maximum current at a pH of about 4. TRPV4 is activated by citrate but not lactate and plays a role in mechano and osmosensation.
TRPC4 and TRPC5 channels form Ca2+ permeable cation channels that are involved in receptor-mediated increases in intracellular Ca2+. They respond to small pH decreases (7.4 to 7.0) by increasing both G protein-activated and channel spontaneous currents. Currents increase when the pH decreases to about 6.5 but are inhibited when pH is decreased further.
TRPP2 (also known as PKD2L1) is currently acknowledged as a pH-sensing channel after it has been discovered as having a major role in sour taste sensing. In order to form functional channels, PKD2L1 needs to associate as a heteromer with other proteins of the PKD1 family1.
References
- Holzer, P. (2009) Handb. Exp. Pharmacol. 194, 283.
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文献和实验All-in-One Kit for Immunohistochemical Staining for Tissues with Antibodies
of your primary antibody. 1) Heat Induced Epitope Retrieval Protocol 2) Based on the reagent that you are using, dilute the reagent to 1X as follows: To 25 ml 20×Citrate Buffer, pH 6.0 solution, add 475 ml distilled water
samples, MPC-15 for 1–15 ml samples and MPC-50 for 15–50 ml samples. Mixer allowing both tilting and rotation. Buffer 1: PBS (without Ca2 and Mg2 ) w/0.1% BSA and 2 mM EDTA, pH 7.4. Buffer 2: PBS pH 7.4 (without Ca2 and Mg2 ).
RAT/MOUSE GROWTH HORMONE ELISA KIT
polyclonal antibodies, 2) wash away of unbound materials from samples, 3) binding of a second biotinylated anti-Growth Hormone polyclonal antibody to the captured molecules, 4) wash away of unbound materials from samples, 5) conjugation of horseradish
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