Store-Operated Ca2+ Channel An

Store-Operated Ca²⁺ Channel Antibody Explorer Kit

A Screening Package of Store-Operated Ca²⁺ Channel Antibodies Economically Priced
Cat #: AK-0209
19 Vials

Alomone Labs is pleased to offer the Store-Operated Ca²⁺ Channel Antibody Explorer Kit (#AK-209). This Explorer Kit includes antibodies targeted against CRAC channels along with their respective peptide control antigen (excludes mouse monoclonal antibodies). An ideal tool for screening purposes.

• Compounds
• Scientific Background
• Related Products

Scientific Background Changes in the cytoplasm free Ca²⁺ concentration [Ca²⁺]_in regulate a large number of relevant physiological processes and have a major impact on cell development and function. The identification of STIM, the endoplasmic reticulum (ER) Ca²⁺ sensor, and Orai, a key subunit of the Ca²⁺ release-activated Ca²⁺ (CRAC) channel pore, have provided the tools to illuminate the mechanisms of CRAC channel regulation, that play an important role in modulation of the free Ca²⁺ concentration in non-excitable cells. Store-operated Ca²⁺ entry (SOCE) is a common and ubiquitous mechanism for regulating Ca²⁺ influx into cells and is widely expressed in most tissues.