Anti-CD59 Polyclonal Antibody

英文名称Rabbit CD59 Polyclonal Antibody别名BMPG;MBP;MBP1;proMBP应用WB稀释比例WB1:500- 2000交叉反应Human蛋白分子量14kDaGene ID966保存Store at -20°C. Avoid freeze / thaw cycles.Stable for one year from the date of shipment.储存液PBS with 0.02% sodium azide, 50% glycerol, pH7.3.纯化方法Affinity purification亚型IgG免疫原Recombinant protein of human CD59性状Lyophilized or LiquidSwiss ProtP13987克隆类型Polyclonal Antibody来源Rabbit背景资料This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.