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- Alomone
- 以色列
- M-100
- 2025年07月10日
- 见官方网站
- Natural protein
- 见官方网站
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- 详细信息
- 技术资料
- 免疫原：
见官方网站
- 亚型：
见官方网站
- 形态：
液体或冻干粉
- 保存条件：
-20°C
- 克隆性：
多克隆
- 标记物：
见官方网站
- 适应物种：
见官方网站
- 保质期：
6个月
- 抗原来源：
Natural protein
- 目录编号：
M-100
- 级别：
高
- 库存：
大量
- 供应商：
上海信裕生物科技有限公司
- 宿主：
Natural protein
- 应用范围：
见官方网站
- 浓度：
见官方网站
- 靶点：
见官方网站
- 抗体英文名：
MitTx
- 抗体名：
MitTx
- 规格：
20 µg, 5 X 20 µg
MitTx
An Activator of ASIC1-Containing ChannelsCat #: M-100
Sizes: 20 µg, 5 X 20 µg
Source: Natural protein
MW: 20.8 kDa. (α subunit, 7.1 kDa. and β subunit, 13.7 kDa.)
Net Peptide Content: 100%
Target: ASIC1 channels
MitTx is a natural toxin isolated from the Texas Coral snake venom1. The purified active toxin consists of a heteromeric complex between Kunitz (α subunit) and phospholipase-A2-like (β subunit) proteins that together function as a potent, persistent and selective agonist for acid-sensing ion channels (ASICs), showing equal or greater efficacy compared with acidic pH1.
MitTx-α and MitTx-β form a high affinity 1:1 complex, and neither subunit demonstrates functional effects on its own1,2.
The purified ASIC-activating component of the venom, MitTx, was found sufficient to elicit robust nocifensive behaviors and is likely responsible for the lasting pain experienced by victims of coral snake envenomation2.
Alomone labs is pleased to offer MitTx (#M-100), a highly purified natural protein, the first described ASIC1 activator.
MitTxReferences
- Bohlen, C.J. et al. (2011) Nature 479, 410.
- Bohlen, C.J. and Julius, D. (2012) Toxicon 60, 254.
- Our Bioassay
- Specifications
- Related Products
Alomone Labs MitTx (α and β subunits, at a stoichometry of 1:1) activates ASIC1a channels heterologously expressed in Xenopus oocytes.
Holding potential was -60 mV. ASIC1a channel was triggered with pH 5.5, where indicated by arrows. 2 nM followed by 20 nM MitTx (#M-100) were used to activate ASIC1a current.
OriginTexas coral snake (Micrurus tener tener).
Purity>98%.
Effective concentration20 nM.
Sequence
MitTx-α subunit:
QIRPAFCYEDPPFFQKCGAFVDSYYFNRSRITCVHFFYGQCDVNQNHFTTMSECNRVCHG.
MitTx-β subunit:
NLNQFRLMIKCTNDRVWADFVDYGCYCVARDSNTPVDDLDRCCQAQKQCYDEAVKVHGCKPLVMFYSFECRYLASDLDCSGNNTKCRNFVCNCDRTATLCILTATYNRNNHKIDPSRCQ.
ModificationsMitTx-α subunit contains pyrrolidone carboxylic acid at the N-terminus.
CAS numberNot determined.
ActivityMitTx activates ASIC1-containing channels1,2.
Storage before reconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
ReconstitutionAny other aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitutionUp to two weeks at 4°C or three months at -20°C.
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