ALK-3 / BMPRIA抗体

ALK-3 / BMPRIA抗体产品信息免疫原 : Mouse ALK-3 / BMPRIA

Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
克隆号 : 002
抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation.
制备方法 : This antibody was obtained from a rabbit immunized with purified, recombinant Mouse ALK-3 / BMPRIA (rM ALK-3 / BMPRIA; Catalog#50078-M08H; NP_033888.2; Met 1-Arg 152).
ALK-3 / BMPRIA抗体 Background
ALK3, also known as BMPR1A, is a type I receptor for bone morphogenetic proteins (BMPs) which belong to the transforming growth factor beta (TGF-β) superfamily. The BMP receptors form a subfamily of transmembrane serine/threonine kinases including the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. Type I and II BMP receptors are both indispensable for signal transduction. Upon ligand binding, they form a heterotetrameric-activated receptor complex consisting of two pairs of a type I and a II receptor. Type II receptors can bind ligands in the absence of type I receptors, whereas the respective type I receptors are required for signal transduction. The downstream molecules of the type I BMP receptors include the Smad (Smad1, 5 and 8) proteins that are phosphorylated in a ligand-dependent manner, and relay the BMP signal from the receptors to target genes in the nucleus. The expression of BMP type I receptors is up-regulated in bone morphogenesis and play central roles during embryonic development and fracture healing. In addition, it has been shown that type 1B and 1A BMP receptors transmit different signals to bone-derived mesenchymal progenitors and function in both the specification and differentiation of osteoblasts and adipocytes. Germline BMPR1A mutations cause a significant proportion of cases of Juvenile polyposis syndrome (JPS).
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