Pregnancy-associated plasma protein-A (PAPP-A, Insulin-like growth factor binding protein-4 protease, PAPP-A-proMBP complex) is a large heterotetrameric glycoprotein of approximately 500 kDa, which was first discovered in serum from pregnant women. The heterotetramer consists of two PAPP-A subunits and two proMBP subunits. Low maternal serum levels of PAPP-A in first trimester biochemical screening is used as a marker of Down’s syndrome (trisomy 21). This antibody is specific for native human PAPP-A.
克隆类型:
Mouse Monoclonal Antibody
亚型:
Mouse IgG1
免疫原:
Purified human PAPP-A
适用物种:
H
应用范围:
E
应用说明:
Product Cat. No. 250219 only detects unreduced PAPP-A in Western Blotting. In a sandwich ELISA with a polyclonal antibody used as a capture reagent, Product Cat. No. 250219 reacts poorly with PAPP-A in third trimester serum. E: 1:20; WB: 1:1,000; IHC: 1:200
别名:
Pregnancy-associated plasma protein A; Pappalysin-1(precursor); Insulin-like growth factor-dependent IGF-binding protein 4 protease; IGF-dependent IGFBP-4 protease; IGFBP-4ase
形态:
Each vial contains 0.2 mg IgG in 0.2 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A/G affinity chromatography.
保存条件:
Store at 4°C. Product is guaranteed 6 months from the date of shipment.