Immunogen:E.coli-derived human PAPP A recombinant protein.
Purification: Immunogen affinity purified
Storage Buffer: PBS, pH 7.4(1%BSA and 0.1% Sodium azide)
Background:
Pappalysin-1, also known as DIPLA1, is a protein that in humans is encoded by the PAPPA gene. It is mapped to 9q33.1. PAPPA is found in the ovarian follicles, follicular fluid, luteal cells, and fallopian tubes of nonpregnant women and in the seminal vesicles and seminal fluid of males. This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses.
Alternate Names:
ASBABP2 antibody;Aspecific BCL2 ARE binding protein 2 antibody;Differentially placenta 1 expressed protein antibody;DIPLA1 antibody;IGF dependent IGFBP 4 protease antibody;IGF-dependent IGFBP-4 protease antibody;IGFBP 4ase antibody.
Specificity Reaction:Hu
Application Notes:WB: 1:100-500 IHC: 1:500-1000
Storage :
Store at –20ºC for one year. Avoid repeated freeze-thaw cycles. At 4ºC for 2-3 weeks after reconstituted.
This product for research use only, not for use in humans, therapeutic or diagnostic procedures.