KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human MDM2.
亚型:
Mouse IgG1
形态:
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 0.2% BSAwith 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
保存条件:
Store at -20°C.
克隆性:
单克隆
标记物:
见下方详细说明
适应物种:
H, M, R
保质期:
1-2年
抗原来源:
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human MDM2.
MDM2 mediates ubiquitination of p53/TP53, leading to its degration by the proteasome. MDM2 inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding to their respective transcriptional activation domains. MDM2 also acts as an ubiquitin ligase towards itself and ARRB1, permits the nuclear export of TP53/p53, and promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein.
克隆类型:
Mouse Monoclonal Antibody
亚型:
Mouse IgG1
免疫原:
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human MDM2.
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 0.2% BSAwith 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
保存条件:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.