北京现货重组人PDCD1(PD-1)(CD279 mutan

特别声明：本产品及我公司所售其他产品均为科研类试剂产品，严禁用于药物、医疗及其他非科研用途。

北京百奥莱博主要从事生物试剂的生产和销*(代"售")，产品线涵盖北京现货重组人PDCD1(PD-1)(CD279 mutant)(国产,进口)在内的分子生物学试剂产品，还包括PCR及荧光定量PCR、核酸提取试剂盒类、样本核酸保护试剂、核酸提取、克隆与转化、蛋白纯化、蛋白检测、免疫组化、细胞凋亡与抗体等。

名称：北京现货重组人PDCD1(PD-1)(CD279 mutant)(国产,进口)
品牌：百奥莱博
英文名：Recombinant Human Programmed Cell Death Protein 1 mutant
产地：国产|进口
编号：JN1527
本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Leu25-Gln167,Cys93Ser在C端含有His标签。

PDCD1/PD-1/CD279 mutant质量控制：＞95%(还原性SDS-PAGE)

PDCD1/PD-1/CD279 mutant制剂：冻干品

PDCD1/PD-1/CD279 mutant保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

PDCD1/PD-1/CD279 mutant复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于PDCD1/PD-1/CD279 mutant：
Programmed cell death protein 1(PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain. PD-1 is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PDCD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PDCD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases. As a cell surface molecule, PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function.

欲咨询购买北京现货重组人PDCD1(PD-1)(CD279 mutant)(国产,进口)，请致电北京百奥莱博科技有限公司，为您提供最全面周到的产品服务，除此之外，我公司正在促销以下产品：
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CYB167062 兔抗猴IgG
ARB11657 人蛋白酶3特异性抗中性粒细胞胞质抗体(PR3-ANCA)ELISA代测服务 Human proteinase-antineutrophil cytoplasmic antibody,pr3-anca ELISA KIT
7791-18-6 Magnesium chloride hexahydrate *化*六水
BL0769 的盒子
BL1292 SDS-PAGE凝胶制备试剂盒
ARB10192 人α肌动蛋白(α Actin)含量测试 Human alpha-actin,α actin ELISA KIT
HC0114 透析袋MD34 (  截留量3500  )
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阿糖尿苷 DL-Arginine 3083-77-0
HC0022 96孔PCR板
L-阿拉伯树胶糖醇 phosphatidylserine 7643-75-6
北京现货重组人PDCD1(PD-1)(CD279 mutant)(国产,进口)关键词：重组人CD279 mutant,JN1527,重组人PDCD1,重组人PD-1,重组人PDCD1蛋白


·重组小鼠IL-27
编号：JN1645
英文名称：Recombinant Mouse Interleukin-27 subunit alpha and Interleukin-27 subunit beta
规格：10μg|50μg|500μg|1mg
本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Tyr19-Pro228&Phe29-Ser234在C端含有His标签。

IL-27质量控制：＞95%(还原性SDS-PAGE)

IL-27制剂：冻干品

IL-27保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

IL-27复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于IL-27：
IL-27 is a heterodimeric cytokine which belongs to the IL-6/IL-12 family of long type I cytokines. It is expressed on monocytes, endothelial cells and dendritic cells. IL-27 is an early product of activated antigen-presenting cells and drives rapid clonal expansion of naive CD4(+) T cells and plays a role in the early regulation of Th1 cells initiation which drives efficient adaptive immune response. IL-27 potentiates the early phase of TH1 response and suppresses TH2 and TH17 differentiation. It induces the differentiation of TH1 cells via two distinct pathways, p38 MAPK/TBX21- and ICAM1/ITGAL/ERK-dependent pathways. It also induces STAT1, STAT3, STAT4 and STAT5 phosphorylation and activates TBX21/T-Bet via STAT1 with resulting IL12RB2 up-regulation, an event crucial to TH1 cell commitment. IL-27 has an antiproliferative activity on melanomas through WSX-1/STAT1 signaling. Thus, IL-27 protein may be an attractive candidate as an antitumor agent applicable to cancer immunotherapy. IL-27 reveals to be a potent inhibitor of TH17 cell development and of IL-17 production. Indeed IL27 alone is also able to inhibit the production of IL17 by CD4 and CD8 T-cells. IL-27 has also an effect on cytokine production. It suppresses proinflammatory cytokine production such as IL2, IL4, IL5 and IL6 and activates suppressors of cytokine signaling such as SOCS1 and SOCS3. Apart from suppression of cytokine production, IL-27 also antagonizes the effects of some cytokines such as IL6 through direct effects on T-cells. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines such as IP-10/CXCL10 and MIG/CXCL9.


北京现货重组人PDCD1(PD-1)(CD279 mutant)(国产,进口)关键词：重组人CD279 mutant,JN1527,重组人PDCD1,重组人PD-1,重组人PDCD1蛋白


·重组小鼠胸腺基质淋巴细胞生成素(TSLP)
编号：JN1366
英文名称：Recombinant Mouse Thymic stromal lymphopoietin
规格：10μg|50μg|500μg|1mg
本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Tyr20-Glu140在C端带有Fc标签。

TSLP质量控制：＞95%(还原性SDS-PAGE)

TSLP制剂：冻干品

TSLP保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

TSLP复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于TSLP：
Thymic stromal lymphopoietin (TSLP) is a protein belonging to the cytokine family, contains 140 amino acids. It is known to play an important role in the maturation of T cell populations through activation of antigen presenting cells. TSLP induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c+ dendritic cells. It can induce allergic inflammation by directly activating mast cells. TSLP is produced mainly by non-hematopoietic cells such as fibroblasts, epithelial cells and different types of stromal or stromal-like cells. These cells are located in regions where TSLP activity is required.

我公司生产供应销*(代"售")的分子生物学试剂产品正全系列现货促销，满分期待您的垂询选购北京现货重组人PDCD1(PD-1)(CD279 mutant)(国产,进口)。