- ￥1344 - 4032
- 卡梅德/KMD Bioscience
- 天津
- KMP2349
- 2025年11月06日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
- 英文名：
Human CD279 Protein, His Tag
- 库存：
999
- 供应商：
卡梅德生物科技（天津）有限公司
- 规格：
10ug/50ug
| 规格： | 10ug | 产品价格： | ￥1344.0 |
|---|---|---|---|
| 规格： | 50ug | 产品价格： | ￥4032.0 |
产品编号：KMP2349
产品名称：Human CD279 Protein, His Tag
中文名称： 重组人CD279蛋白
中文全称：重组人程序性死亡分子蛋白
产品描述：产品描述：The Human CD279 Protein(KMP2349) is produced in HEK293 Cells and the target gene encoding Leu25-Gln167 is expressed with a 6His tag at the C-terminus.
产品别称：程序性死亡分子, Programmed cell death protein 1
分子名称：CD279
预测分子量：16.78 kDa
物种：Human
宿主：HEK293 Cells
规格：50ug, 100ug, 200ug
纯化方式：Affinity purification
纯度：>95% as determined by SDS-PAGE
内毒素水平：<1.0 EU/ug determined by the LAL method
缓冲体系：PBS, pH7.4
Uniport:Q9UM82
功能：Bridging factor that mediates the recruitment of CYLD to the LUBAC complex, thereby regulating TNF-alpha-induced necroptosis (PubMed:27307491, PubMed:27458237, PubMed:27545878, PubMed:27591049). Acts as a direct binding intermediate that bridges RNF31/HOIP, the catalytic subunit of the LUBAC complex, and the deubiquitinase (CYLD), thereby recruiting CYLD to the TNF-R1 signaling complex (TNF-RSC) (PubMed:27458237, PubMed:27545878, PubMed:27591049). Required to activate the 'Met-1'- (linear) and 'Lys-63'-linked deubiquitinase activities of CYLD (PubMed:27458237, PubMed:27591049). Controls the kinase activity of RIPK1 and TNF-alpha-induced necroptosis by promoting 'Met-1'-linked deubiquitination of RIPK1 by CYLD (By similarity).
产品背景：Programmed cell death protein 1(PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain. PD-1 is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PDCD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PDCD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases. As a cell surface molecule, PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function.
保存条件：Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
运输条件：In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
说明：This product is for research use only.
参考文献：1.EMBO J. 35:1868-1884 (2016) 2.EMBO Rep. 17:1485-1497 (2016) 3.Cell Rep. 16:2271-2280 (2016) 4.Mol. Cell 63:990-1005 (2016)
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