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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
+4°C 干燥
- 保质期:
12个月
- 英文名:
CGP 37849
- 供应商:
上海汇谱仪器有限公司
- CAS号:
127910-31-0
- 规格:
10 mg
概述
- 产品名称
CGP 37849 - 描述
Competitive NMDA antagonist - 生物学描述
Competitive NMDA receptor antagonist (Ki = 35 nM for displacement of CPP binding in rat brain). Potent oral anticonvulsant activity in vivo. - 纯度
> 99%
性能
- 化学名称
(E)-(±)-2-Amino-4-methyl-5-phosphono-3-pentenoic acid - 分子量
209.14 - 化学结构

- 分子式
C6H12NO5P - CAS编号
127910-31-0 - PubChem识别号
5950212 - 存放说明
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. - 溶解度概述
Soluble in water to 100 mM (with warming) - 处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- SMILES
C/C(=CC(N)C(=O)O)CP(=O)(O)O - 来源
Synthetic
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文献和实验Characterization of Wild‐Type Excitatory Amino Acid Ion Channel Receptors
‐4‐methyl‐5‐phosphono‐3‐pentanoic acid ([3 H]CGP 37849) N ‐methyl‐D‐aspartate (NMDA), L‐glutamate, or CGS 19755 (Sigma; RBI
Cytokine Gene Polymorphisms: Methods of Detection and Biological Significance
. An important aspect of CGP analyses is the correct interpretation of results particularly determination of their multilocus haplotypes.
被普遍采用,并且定性的性质使得结果的解释难以细化。另一种方法是检测肿瘤基因组中的新抗原;然而,这依赖于整个外显子组和转录组测序,这可能是非常昂贵和耗时的。TMB的测定为新抗原检测提供了一种替代方法,使用突变率本身作为新抗原负担的代理。全面的基因组分析TMB已经被证明可以预测免疫治疗的反应,当使用整个外显子组测序,基因组的所有编码区域(约20,000个基因)的测序。在这项研究中,我们测试了TMB是否可以通过315个基因的靶向综合基因组谱(CGP)来精确测量。我们发现CGP的测定与整个外显子组的测定高度
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