Levcromakalim左克罗卡林,94535-50-9

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Levcromakalim

CAS No. : 94535-50-9

MCE 国际站：Levcromakalim

产品活性：Levcromakalim ((-)-Cromakalim) 是 ATP 敏感性的 K⁺ 通道 (K_ATP) 激活剂。

研究领域：Membrane Transporter/Ion Channel

作用靶点：Potassium Channel

In Vitro: Levcromakalim ((-)-Cromakalim) inhibits spontaneous contractions completely in a glibenclamide-sensitive manner. LevCromakalim (5 μM) inhibits spontaneous contractions, which are recovered by glibenclamide. Levcromakalim (1, 5 and 10 μM) inhibits phasic contractions to 34±21.1%, 20.1±20.0% and 0% of the control (n=5, respectively; P<0.05). Glibenclamide reverses the inhibition of spontaneous isometric contractions caused by LevCromakalim (5 μM) to 84±1.5% of the control (n=5; P<0.05). Levcromakalim (20 and 100 μM) also inhibits oxytocin (OXT) (10 nM)-induced phasic contractions to 34±21.4% and 14±12.6% of the control (n=6 and 4, respectively; P<0.05). Glibenclamide reverses the inhibition of spontaneous isometric contractions by LevCromakalim (100 μM) to 79±3.5% of the control (n=4; P<0.05). Tonic contraction by OXT is also suppressed by Cromakalim in a glibenclamide-sensitive manner.The function of the K_ATP channels is examined with the specific channel opener LevCromakalim (Cromakalim). LevCromakalim induces dose-dependent relaxation in both the young and old mesenteric artery (MAs); and there is no difference in relaxation with age. However, the relaxation is markedly reduced in response to the high-salt (HS) diet in the old MAs (P<0.05).

相关产品：Bioactive Compound Library Plus  |  Membrane Transporter/Ion Channel Compound Library  |  Anti-Cardiovascular Disease Compound Library  |  Neuroprotective Compound Library  |  Potassium Channel Compound Library  |  Membrane Protein-targeted Compound Library  |  Membrane Receptor-targeted Compound Library  |  Ion Channel Compound Library  |  Nigericin sodium salt  |  Yoda 1  |  BAPTA-AM  |  Minocycline hydrochloride  |  Branaplam  |  Rosuvastatin Calcium  |  SCH-23390 hydrochloride  |  Glibenclamide  |  Quinidine (15% dihydroquinidine)  |  Tetrandrine  |  Carbamazepine  |  20(S)-Ginsenoside Rg3  |  DCPIB  |  E-4031  |  Amiodarone hydrochloride  |  Minoxidil  |  TRAM-34  |  Tannic acid  |  (±)-Naringenin  |  Quinine  |  Terfenadine  |  SKF-96365 hydrochloride  |  Mefloquine hydrochloride  |  4-Aminopyridine  |  GW9508  |  PAP-1  |  Astemizole  |  Flufenamic acid  |  Guanosine 5'-diphosphate disodium salt  |  Tolbutamide

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds