人 TNFSF10 过表达腺病毒产品信息

人 TNFSF10 过表达腺病毒产品信息

订购信息

货号	种属	载体	描述	荧光	价格	周期
HZ003810	Human	腺病毒	Homo sapiens tumor necrosis factor (ligand) superfamily, member 10(TNFSF10，TRAIL), mRNANM_003810	带绿色荧光	8000 7000	现货

基本信息

基因名称：	TNFSF10
基因别名：	Apo-2L; APO2L; CD253; TL2; TRAIL
NCBI序列号：	NM_003810
基因描述：	Homo sapiens tumor necrosis factor (ligand) superfamily, member 10(TNFSF10，TRAIL), mRNA NM_003810
基因种属：	Human
荧光标记：	带绿色荧光
腺病毒滴度：	109~1010pfu/ml

产品说明书

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基因简介

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.