Homo sapiens tumor necrosis factor (ligand) superfamily, member 10(TNFSF10,TRAIL), mRNANM_003810
带绿色荧光
8000 7000
现货
基本信息
基因名称:
TNFSF10
基因别名:
Apo-2L; APO2L; CD253; TL2; TRAIL
NCBI序列号:
NM_003810
基因描述:
Homo sapiens tumor necrosis factor (ligand) superfamily, member 10(TNFSF10,TRAIL), mRNA NM_003810
基因种属:
Human
荧光标记:
带绿色荧光
腺病毒滴度:
109~1010pfu/ml
产品说明书
请联系沪震技术支持索取产品说明书。
基因简介
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.