- ￥610 - 710
- TargetMol
- 美国
- T3826
- 2025年07月09日
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- 详细信息
- 技术资料
- 保存条件：
零下80~20°C
- 保质期：
Powder: -20°C for 3 years In solvent: -80°C for 2 years
- 英文名：
Polygalasaponin F
- 库存：
10
- 供应商：
TargetMol
- CAS号：
882664-74-6
- 规格：
20 mg/1 mL
| 规格： | 20 mg | 产品价格： | ￥610.0 |
|---|---|---|---|
| 规格： | 1 mL | 产品价格： | ￥710.0 |
Product Introduction
Bioactivity
英文名:Polygalasaponin F
描述:Polygalasaponin F has anti-neuroinflammatory activity, can inhibit the release of inflammatory cytokines TNF-α and NO induced by lipopolysaccharides (LPS) and reduce the expression of inducible nitric oxide synthases. Polygalasaponin F can significantly inhibit the cytotoxicity of conditioned medium prepared by LPS-stimulated BV-2 microglia (LPS conditioned media) to neuronal PC12 cells and improve cell viability. Polygalasaponin F can induce long-term potentiation in hippocampal dentate gyrus in anesthetized rats via NMDAR activation mediated by Ca(2+)/calmodulin-dependent kinase II, extracellular signal-regulated kinase and cAMP response element-binding protein signaling pathway. PS-F inhibits the secretions of neuroinflammatory cytokines by the regulation of the NF-kB-signaling pathway.
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