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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1416561-90-4
- 规格：
10 mM * 1 mL///1 mg
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O-Propargyl-Puromycin
CAS No. : 1416561-90-4
MCE 国际站：O-Propargyl-Puromycin
产品活性：O-Propargyl-Puromycin 是嘌呤霉素的炔类似物; 是蛋白质合成的高效抑制剂。O-Propargyl-Puromycin 是一种点击化学试剂。它含有 Alkyne 基团，可以和含有 Azide 基团的分子发生铜催化的叠氮-炔环加成反应 (CuAAc)。
研究领域：Others
作用靶点：Others
In Vitro: O-propargyl-puromycin can be used to image and affinity-purify nascent proteins in cells and in animals. O-propargyl-puromycin inhibits protein synthesis, both in reticulocyte lysates and in cultured cells, displaying a potency two- to threefold lower than that of unmodified puromycin. O-propargyl-puromycin forms covalent conjugates with nascent polypeptide chains, which are rapidly turned over by the proteasome and can be visualized or captured by copper(I)-catalyzed azide-alkyne cycloaddition.
In Vivo: Tissues from uninjected mice shows low nonspecific staining, whereas tissues from O-propargyl-puromycin-injected mice display specific patterns of O-propargyl-puromycin incorporation into nascent proteins. In the small intestine, translation is strongest in cells in the crypts and at the base of intestinal villi, consistent with the high proliferative and secretory activity of these cells. The stain is particularly strong in Paneth cells, which are located close to the base of the crypts and are filled with secretory vesicles. The intense O-propargyl-puromycin labeling of vesicles in Paneth cells suggests that prematurely terminated, O-propargyl-puromycin-conjugated secretory proteins are translocated into the endoplasmic reticulum (ER) lumen.
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文献和实验Carbohydrate‐Oligonucleotide Conjugates
). View Image Figure 4.38.3 Synthesis of 1‐ O ‐propargyl‐2,3,4,6‐tetra‐ O ‐acetyl‐α‐D ‐mannopyranoside (S.11
Nucleoside Modification with Boron Clusters and Their Metal Complexes
in mineral oil Propargyl alcohol, 99% pure Toluene, anhydrous, 99.7% pure
protein, GFP, or the selectable puromycin resistancegene, linked to the expressing of SaCas9 via a 2A peptidelinker. These constructs will enable fl uorescence activated cellsorting (FACS) or the selection of transfected population
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