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- 英文名：
PSI-938
- 库存：
货期：询盘
- 供应商：
MedChemExpress LLC
- CAS号：
1199809-32-9
- 规格：
询盘
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PSI-352938
CAS No. : 1231747-17-3
MCE 国际站：PSI-352938
产品活性：PSI-352938 (PSI-938) 是一种丙型肝炎病毒 (HCV) 核苷酸抑制剂。
研究领域：Anti-infection
作用靶点：HCV
In Vitro: PSI-352938 (PSI-938) and PSI-353661 inhibit HCV genotype (GT) 1b replicon replication with 50% effective concentrations (EC50s) of 0.13±0.076 μM and 3.0±1.4 nM, respectively, and are similarly active against GT 1a and 2a replicons and infectious viruses. Metabolism of PSI-352938 and PSI-353661 generates the same 5′-triphosphate metabolite, PSI-352666, which is similarly active against NS5B polymerases from GT 1 to 4. PSI-352938 (PSI-938) is a novel cyclic phosphate prodrug of β-D-2′-deoxy-2′-α-fluoro-2′-β-C-methylguanosine 5′-monophosphate that has potent activity against HCV. PSI-352938 (PSI-938) has similar activity against genotype 1a, 1b, and 2a replicons, with EC50s ranging from 0.13 to 0.20 μM and EC90 values ranging from 0.35 to 0.74 μM. PSI-352938 (PSI-938) also effectively inhibits HCV replication in the infectious virus assays: the EC50 and EC90 values are 0.28±0.083 μM and 0.63±0.018 μM, respectively, against the H77 infectious virus and 0.39±0.31 μM and 1.16±0.64 μM, respectively, against the JFH-1 infectious virus. In contrast, PSI-352938 is not active against HBV or HIV up to the highest concentration tested (EC50>100 μM).
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文献和实验buffer for 1 L 25 mM Tris 3.03 g 1 mM Na2 EDTA (pH 8.0) 0.37 g 5 mM b-mercaptoethanol 390 µl 1) Thaw cells. 2) Innoculate 10 ml of LB amp media and grow cells overnight @ 32°C 3) Aliquot 1 ml of culture for glycerol permeant, store
-mercaptoethanol 390 µl 1) Thaw cells. 2) Innoculate 10 ml of LB amp media and grow cells overnight @ 32°C 3) Aliquot 1 ml of culture for glycerol permeant, store at -80°C. 4) Pour remaining preculture into 300 ml of LB broth. --> NOTE: Set
4 + 50 ml H20 = 1 M solution mix 32.4 ml 1M K2HPO4 + 7.6 ml 1 M KH2PO4 to get pH7.5 300 mM K citrate, pH 7.5 6.3 g citric acid + ~70 ml H20 add HCL or 10N KOH to pH to 7.5 H20 to 100 ml c) recovery buffer : M9 buffer. People used
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