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上海研谨生物科技有限公司
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文献和实验The TRPP Signaling Module: TRPP2/Polycystin-1 and TRPP2/PKD1L1
TRPP ion channels assemble with polycystin-1 family proteins into receptor-channel complexes. TRPP2–Polycystin-1 is required to coordinate renal three-dimensional tissue organization, whereas TRPP2–PKD1L1 is essential for establishment
when there is evidence that the disease is of clonal origin. We recently identified the FIP1L1-PDGFRA fusion gene in approx 50% of HES/CEL cases (5 ). Fusion of FIP1L1 to PDGFRA is the consequence of a deletion on chromosome 4, del(4)(q12q12), with the centromeric
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