Ju Huang, et al. Mater Today Bio. 2023 Apr; 19: 100555. PMID: 36793322 Oxygen-carrying nanoplatform to reprogram tumor immunosuppressive microenvironment and enhance photothermal-immunotherapy
BMDC细胞介绍
华拓细胞库:BMDC小鼠树突状细胞 Mouse bone marrow dendritic cells were isolated from bone marrow. Bone marrow DC cells were induced by bone marrow monocytes. Dendritic cells can be divided into mature dendritic cells and immature dendritic cells. Typical immature dendritic cells grow semi-adherent and form grape cluster colonies under the action of GM-CSF and IL4. The cells are large and irregular in shape, with many surface folds and a few short spines, abundant intracellular organelles and phagocytic vesicles, and have strong migration ability. There are some monocytes that are not completely induced, and the adhesion forms are various. Mature dendritic cells were further induced from immature DC by TNF-α and LPS, and most of them grew in suspension, with round cells and further enlarged cell size, a large number of dendritic protrtions of varying thickness on the surface, accompanied by a small number of adherent immature cells or monocytes. Prolonged culture of immature DC cells may also lead to spontaneous differentiation and maturation.
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