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- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
α-Mangostin
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
6147-11-1
- 规格：
10 mM * 1 mL/10 mg/50 mg/100 mg/250 mg/500 mg/1 g
| 规格： | 10 mM * 1 mL | 产品价格： | ￥205.0 |
|---|---|---|---|
| 规格： | 10 mg | 产品价格： | ￥187.0 |
| 规格： | 50 mg | 产品价格： | ￥332.0 |
| 规格： | 100 mg | 产品价格： | ￥630.0 |
| 规格： | 250 mg | 产品价格： | ￥950.0 |
| 规格： | 500 mg | 产品价格： | ￥1330.0 |
| 规格： | 1 g | 产品价格： | ￥1850.0 |
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alpha-Mangostin
CAS No. : 6147-11-1
MCE 国际站：alpha-Mangostin
产品活性：alpha-Mangostin (α-Mangostin) 是具有广泛生物活性的膳食呫吨酮，如抗氧化剂，抗过敏，抗病毒，抗菌，抗炎和抗癌作用。它是IDH1突变体 (IDH1-R132H) 的抑制剂，Ki值为 2.85 μM。
研究领域：Immunology/Inflammation | NF-κB | Metabolic Enzyme/Protease | Apoptosis | Anti-infection
作用靶点：Reactive Oxygen Species | Apoptosis | Bacterial | Fungal | Virus Protease
In Vitro: alpha-Mangostin (α-Mangostin) exhibits a selective inhibitory effect on IDH1-R132H, but not on IDH1. alpha-Mangostin (α-Mangostin) competitively inhibits the binding of alpha-mangostin (α-KG) to IDH1-R132H. The structure–relationship study reveals that alpha-Mangostin (α-Mangostin) exhibits the strongest core inhibitor structure. alpha-Mangostin (α-Mangostin) selectively promotes demethylation of 5-methylcytosine (5mC) and histone H3 trimethylated lysine residues in IDH1 (+/R132H) MCF10A cells. Cell proliferation significantly decreases in a dose-dependent manner in the cells treated with alpha-mangostin. Alpha-mangostin also increases the levels of Bax (pro-apoptotic), cleaved caspase-3, cleaved caspase-9 and cleaved-poly(ADP-ribose) polymerase (PARP). alpha-Mangostin (α-Mangostin) significantly inhibits light-induced degeneration of photoreceptors and 200 μM H2O2-induced apoptosis of RPE cells. 200 μM H2O2-induced generation of reactive oxygen species (ROS) and light-induced generation of malondialdehyde (MDA) are suppressed by alpha-Mangostin (α-Mangostin).
In Vivo: alpha-Mangostin (α-Mangostin) reduces risk of liver fibrosis through the decrease in p53 expression as compared to the TAA_DMSO treatment. The serum levels of the liver enzymes AST and ALT after treatment with α-mangostin decrease as compared to DMSO alone.
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