alpha-Mangostin (Standard)α-倒捻

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

alpha-Mangostin (Standard)

CAS No. : 6147-11-1

MCE 国际站：alpha-Mangostin (Standard)

产品活性：alpha-Mangostin (Standard) 是 alpha-Mangostin 的分析标准品。本产品用于研究及分析应用。alpha-Mangostin (α-Mangostin) 是具有广泛生物活性的膳食呫吨酮，如抗氧化剂，抗过敏，抗病毒，抗菌，抗炎和抗癌作用。它是IDH1突变体 (IDH1-R132H) 的抑制剂，K_i值为 2.85 μM。

研究领域：Anti-infection  |  Metabolic Enzyme/Protease  |  Apoptosis  |  Immunology/Inflammation  |  NF-κB

作用靶点：Fungal  |  Bacterial  |  Virus Protease  |  Reactive Oxygen Species  |  Apoptosis

In Vitro: alpha-Mangostin (α-Mangostin) exhibits a selective inhibitory effect on IDH1-R132H, but not on IDH1. alpha-Mangostin (α-Mangostin) competitively inhibits the binding of alpha-mangostin (α-KG) to IDH1-R132H. The structure–relationship study reveals that alpha-Mangostin (α-Mangostin) exhibits the strongest core inhibitor structure. alpha-Mangostin (α-Mangostin) selectively promotes demethylation of 5-methylcytosine (5mC) and histone H3 trimethylated lysine residues in IDH1 (+/R132H) MCF10A cells. Cell proliferation significantly decreases in a dose-dependent manner in the cells treated with alpha-mangostin. Alpha-mangostin also increases the levels of Bax (pro-apoptotic), cleaved caspase-3, cleaved caspase-9 and cleaved-poly(ADP-ribose) polymerase (PARP). alpha-Mangostin (α-Mangostin) significantly inhibits light-induced degeneration of photoreceptors and 200 μM H₂O₂-induced apoptosis of RPE cells. 200 μM H₂O₂-induced generation of reactive oxygen species (ROS) and light-induced generation of malondialdehyde (MDA) are suppressed by alpha-Mangostin (α-Mangostin).

In Vivo: alpha-Mangostin (α-Mangostin) reduces risk of liver fibrosis through the decrease in p53 expression as compared to the TAA_DMSO treatment. The serum levels of the liver enzymes AST and ALT after treatment with α-mangostin decrease as compared to DMSO alone.

相关产品：MG-132  |  Ferrostatin-1  |  Rapamycin  |  Cycloheximide  |  Doxorubicin hydrochloride  |  Bafilomycin A1  |  Tamoxifen  |  LY294002  |  Y-27632  |  Paclitaxel  |  Dexamethasone  |  Dimethyl sulfoxide  |  Acetylcysteine  |  Angiotensin II human  |  Puromycin dihydrochloride  |  2-Deoxy-D-glucose  |  Staurosporine  |  H2DCFDA  |  Actinomycin D  |  SB-431542  |  Bortezomib  |  Deferoxamine mesylate  |  5-Fluorouracil  |  Trametinib  |  Oxaliplatin  |  Sorafenib  |  Temozolomide  |  Gemcitabine  |  G-418 disulfate  |  MitoSOX Red

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds