AXIN1抗体AXIN1兔多抗抗体Protein phosp
hatase 1 regulatory subunit 49 antibody抗体AXIN1 Antibody抗体- ￥440 - 1320
- CUSABIO
- CN
- CSB-PA517675LA01HU
- 2025年07月15日
- ELISA, IHC; Recommended dilution: IHC:1:20-1:200
- Rabbit
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Recombinant Human Axin-1 protein (418-707AA)
- 亚型：
IgG
- 形态：
Liquid
- 保存条件：
Upon receipt, store at -20℃ or -80℃. Avoid repeated freeze.
- 克隆性：
Polyclonal
- 标记物：
Non-conjugated
- 适应物种：
Human
- 保质期：
6个月
- 抗原来源：
Homo sapiens (Human)
- 目录编号：
O15169
- 级别：
优
- 库存：
200
- 供应商：
武汉华美生物工程有限公司
- 宿主：
Rabbit
- 应用范围：
ELISA, IHC; Recommended dilution: IHC:1:20-1:200
- 浓度：
>95%,Protein G purified
- 靶点：
AXIN1
- 抗体英文名：
AXIN1 Antibody
- 抗体名：
Protein phosphatase 1 regulatory subunit 49 antibody
- 规格：
100μg/50μg/20μg
| 规格： | 100μg | 产品价格： | ￥1320.0 |
|---|---|---|---|
| 规格： | 50μg | 产品价格： | ￥880.0 |
| 规格： | 20μg | 产品价格： | ￥440.0 |
保存缓冲液
Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
功能
Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development.风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验Two-hybrid analysis of genetic regulatory networks
. (1993). The retinoblastoma protein associates with the protein phophatase type 1 catalytic subunit. Genes and Dev. 7 , 555-569. Estojak, J., Brent, R., and Golemis, E. A. (1995). Correlation of two-hybrid affinity data with in vitro measurements
for differences in peptide masses of 80 Da that are not found in the unphosphorylated peptide control can identify phosphopeptides. Phosphopeptides can also be identified by treating one of two identical samples with protein phosphatase to liberate phosphate
卫民.丙型肝炎病毒抗体的时间分辨荧光分析法检测[J].临床检验杂志,2001,19(4): 215.[34] 王蕾,吴英松,汤永平,等.应用时间分辨荧光免疫分析技术检测SARS 病毒抗原的初步研究[J].第一军医大学学报,2005,25(4): 429-433.[35] P A Christopher Maple,Cerys S Jones.Time-resolved fluorometric immunoassay for rubella antibody—
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