SNAIL&SLUG Rabbit pAb(bs-11961R)-50ul/100ul/200ul产品图
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SNAIL&SLUG Rabbit pAb(bs-11961

R)-50ul/100ul/200ul
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  • ￥1180 - 2800
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  • bs-11961R
  • 2026年10月14日
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    北京博奥森生物技术有限公司
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      50ul/100ul/200ul

    规格：50ul产品价格：￥1180.0
    规格：100ul产品价格：￥1980.0
    规格：200ul产品价格：￥2800.0
    产品编号bs-11961R
    英文名称SNAIL + SLUG Rabbit pAb
    中文名称锌指转录因子Slug+SNAIL抗体
    英文别名SNAIL+SLUG; dJ710H13.1; Protein sna; Protein snail homolog; SLUGH2; SNA; Sna protein; SNAH; SNAI1; Snail homolog 1(Drosophila); Zinc finger protein SNAI1; SNAI1_HUMAN; Protein snail homolog 1; dJ710H13.1; SNAIL; SNAIL1; Protein sna; Neural crest transcription factor Slug; Protein snail homolog 2; Slug(chicken homolog) zinc finger protein; Slug homolog zinc finger protein; Slug zinc finger protein; SLUGH 1; SLUGH; SLUGH1; SNAI 2; SNAI2; SNAI-2; SNAI2_HUMAN; Snail 2; Snail homolog 2; Snail2; Snail-2; WS 2D; WS2D; Zinc finger protein SLUG; Zinc finger protein SNAI2.
    产品应用WB=1:500-2000, Flow-Cyt=1μg/Test

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应Human, Mouse, Rat (Chicken, Dog, Pig, Cow, Rabbit, Sheep, GuineaPig, Danio rerio)
    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human SNAIL + SLUG
    亚型IgG
    性状Liquid
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    理论分子量30 kDa
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    亚基Interacts (via SNAG domain) with LIMD1 (via LIM domains), WTIP (via LIM domains) and AJUBA (via LIM domains) (By similarity). Interacts (via zinc fingers) with KPNA2, KPNB1, and TNPO1. May interact (via zinc fingers) with IPO7.
    亚细胞定位Nucleus. Cytoplasm. Note=Observed in discrete foci in interphase nuclei. These nuclear foci do not overlap with the nucleoli, the SP100 and the HP1 heterochromatin or the coiled body, suggesting SNAI2 is associated with active transcription or active splicing regions.
    组织特异性Expressed in most adult human tissues, including spleen, thymus, prostate, testis, ovary, small intestine, colon, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Not detected in peripheral blood leukocyte. Expressed in the dermis and in all layers of the epidermis, with high levels of expression in the basal layers (at protein level). Expressed in osteoblasts (at protein level). Expressed in mesenchymal stem cells (at protein level). Expressed in breast tumor cells (at protein level).
    翻译后修饰GSK3B-mediated phosphorylation results in cytoplasmic localization and degradation.
    相似性Belongs to the snail C2H2-type zinc-finger protein family.
    Contains 5 C2H2-type zinc fingers.
    功能Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells. Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.

     

    应用推荐稀释比例
    {WB}{1:500-2000}
    {Flow-Cyt}{1μg/Test}

     

    产品细节图片1
    Blank control (blue line): Hela (fixed with 70% methanol (Overnight at 4℃) and then permeabilized with 90% ice-cold methanol for 20 min at -20℃).
    _x000D_ Primary Antibody (green line): Rabbit Anti-SNAIL + SLUG antibody (bs-11961R),_x000D_ Dilution: 1μg /10^6 cells;
    _x000D_ Isotype Control Antibody (orange line): Rabbit IgG .
    _x000D_ Secondary Antibody (white blue line): Goat anti-rabbit IgG-PE,Dilution: 1μg /test.
    _x000D_
    产品细节图片2
    Blank control: HepG2.
    _x000D_ Primary Antibody (green line): Rabbit Anti-SNAIL+SLUG antibody (bs-11961R)
    _x000D_ Dilution: 2μg /10^6 cells;
    _x000D_ Isotype Control Antibody (orange line): Rabbit IgG .
    _x000D_ Secondary Antibody : Goat anti-rabbit IgG-AF488
    _x000D_ Dilution: 1μg /test.
    _x000D_ Protocol
    _x000D_ The cells were fixed with 4% PFA (10min at room temperature)and then permeabilized with 90% ice-cold methanol for 20 min at-20℃. The cells were then incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed._x000D_
    产品细节图片3
    Heart Cell(mouse) Lysate at 40 ug
    _x000D_ Primary: Anti- SNAIL + SLUG (bs-11961R) at 1/300 dilution
    _x000D_ Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    _x000D_ Predicted band size: 30 kD
    _x000D_ Observed band size: 30 kD
    _x000D_
    产品细节图片4
    Sample:_x000D_ Heart Cell(Rat) Lysate at 40 ug
    _x000D_ Primary: Anti- SNAIL + SLUG (bs-11961R) at 1/300 dilution
    _x000D_ Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    _x000D_ Predicted band size: 30 kD
    _x000D_ Observed band size: 30 kD
    _x000D_
    产品细节图片5
    Sample:
    _x000D_ H9C2 Cell(Rat) Lysate at 30 ug
    _x000D_ HUVEC Cell(Human) Lysate at 30 ug
    _x000D_ MAD-MB-231 Cell(Human) Lysate at 30 ug
    _x000D_ 293T Cell(Human) Lysate at 30 ug
    _x000D_ Primary: Anti- SNAIL + SLUG (bs-11961R) at 1/300 dilution
    _x000D_ Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    _x000D_ Predicted band size: 30 kD
    _x000D_ Observed band size: 30 kD
    _x000D_

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    SNAIL&SLUG Rabbit pAb(bs-11961R)-50ul/100ul/200ul
    ￥1180 - 2800