The blue histogram is unstained cells(HepG 2).
The Wathet Blue histogram is cells stained with secondary antibody alone.The Orange histogram is cells stained with rabbit IgG isotype control antibody plus secondary antibody.
The green histogram is cells stained with Rabbit Anti-DOK5 antibody (bs-8587R) plus secondary antibody.5μg in 100μL 1 X PBS containing 0.5% BSA.
- ￥1180 - 2800
- Bioss
- bs-8587R
- 2025年10月16日
- 产品信息以Bioss网站为准
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50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-8587R |
| 英文名称 | DOK5 Rabbit pAb |
| 中文名称 | 胞浆接头蛋白Dok5抗体 |
| 英文别名 | chromosome 20 open reading frame 180; Docking protein 5; DOK 5; DOK5 protein; downstream of tyrosine kinase 5; IRS6; DOK5_HUMAN. |
| 产品应用 | Flow-Cyt=5μg/Test Not yet tested in other applications. |
| 交叉反应 | Human (Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human DOK5/IRS6 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 34 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Signal Transduction > Adapters > Transmembrane Signal Transduction > Protein Phosphorylation > Ser / Thr Kinases > MAPK Pathway Signal Transduction > Protein Phosphorylation > Tyrosine Kinases > Receptor Tyrosine Kinases |
| 亚基 | Interacts with phosphorylated RET. In contrast to other DOK proteins, it does not interact with RASGAP (By similarity). |
| 组织特异性 | Highest expression in skeletal muscle, lower in brain, heart and kidney. Also detected in activated peripheral blood T-lymphocytes. |
| 翻译后修饰 | Phosphorylated on tyrosine residues in response to insulin, IGF1 and GDNF. |
| 相似性 | Belongs to the DOK family. Type B subfamily.
Contains 1 IRS-type PTB domain. Contains 1 PH domain. |
| 功能 | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The downstream of kinase family (Dok-1-7) are members of a class of “docking” proteins that include the tyrosine kinase substrates IRS-1 and Cas, which contain multiple tyrosine residues and putative SH2 binding sites. Dok-4 and Dok-5 are more similar to each other than to the other Dok family members, and may constitute a subfamily of the DOK genes. Dok-5 is a tyrosine kinase substrate that enhances c-Ret-dependent activation of mitogen-activated protein kinase (MAPK). Dok-5 transcript is abundant in muscle and increases during T cell activation. Dok-5 protein undergoes tyrosine phosphorylation in response to Insulin and Insulin-like growth factor-1. The gene encoding human Dok-5 maps to chromosomal location 20q13.2. |
| 应用 | 推荐稀释比例 |
| {Flow-Cyt} | {5μg/Test} |
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文献和实验该产品被引用文献
[IF={{ 2.03 }}] {Pan, Yanfang, et al. "Dok5 is involved in the signaling pathway of neurotrophin-3 against TrkC-induced apoptosis." Neuroscience Letters (2013).} {IF} {="Mouse"}
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DOK5 Rabbit pAb(bs-8587R)-50ul/100ul/200ul
￥1180 - 2800
