Sample: Cerebellum(Rat) Tissue Lysate at 40 ug
Primary: Anti-KDM6B(bs-20004R)at 1:300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1:20000 dilution
Predicted band size: 177 kD
Observed band size: 177 kD
- ￥1180 - 2800
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- bs-20004R
- 2025年10月16日
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- 规格：
50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-20004R |
| 英文名称 | KDM6B Rabbit pAb |
| 中文名称 | 组蛋白去甲基化酶JMJD3抗体 |
| 英文别名 | Histone demethylase JMJD3; JmjC domain containing protein 3; JmjC domain-containing protein 3; Jumonji D3; Jumonji domain containing 3; Jumonji domain containing 3 histone lysine demethylase; Jumonji domain containing protein 3; Jumonji domain-containing protein 3; Kdm6b; KDM6B_HUMAN; KIAA0346; Lysine demethylase 6B; Lysine K specific demethylase 6B; Lysine specific demethylase 6B; Lysine-specific demethylase 6B. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 交叉反应 | Rat (Human, Mouse, Pig, Cow, Horse, Rabbit, Sheep) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human KDM6B |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 177 kDa |
| 浓度 | 1mg/ml |
| 储存液 | Preservative: 0.02% Proclin300, Constituents: 1% BSA, 0.01M PBS, pH7.4. |
| 研究领域 | Epigenetics and Nuclear Signaling > Chromatin Modifying Enzymes > Jumonji containing proteins Epigenetics and Nuclear Signaling > Transcription > Domain Families > Developmental Families > HOX |
| 亚细胞定位 | Nucleus. |
| 相似性 | Belongs to the UTX family.
Contains 1 JmjC domain. |
| 功能 | Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | JMJD3 is a 1,679 amino acid nuclear protein that contains one JmjC domain and belongs to the highly conserved JmjC domain-containing protein family. Functioning as a histone demethylase, JMJD3 uses iron and ascorbate as cofactors to demethylate dimethylated and trimethylated Lys-27 residues of Histone H3, thereby playing an important role in the modification of the histone code. Additionally, JMJD3 regulates posterior development and is involved in the inflammatory response, specifically by mediating macrophage differentiation. JMJD3 is also thought to control the expression of neurogenesis-related proteins and, via this regulatory mechanism, may be necessary for neural commitment during early development. Two isoforms of JMJD3 exist due to alternative splicing events. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
Sample:
Cerebellum (Rat) Lysate at 40 ug
Primary: Anti-KDM6B (bs-20004R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 177 kD
Observed band size: 177 kD
Cerebellum (Rat) Lysate at 40 ug
Primary: Anti-KDM6B (bs-20004R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 177 kD
Observed band size: 177 kD
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文献和实验该产品被引用文献
[IF={{ 5.3 }}] {Wenkai Yu. et al. KDM6B knockdown alleviates sleep deprivation-induced cerebrovascular lesions in APP/PS1 mice by inhibiting PARP16 expression. BIOCHEM PHARMACOL. 2025 Jan;231:116650} {WB} {Mouse}
[IF={{ 2.8 }}] {Zhuang Cuicui. et al. Lycopene promoted M2 macrophage polarization via inhibition of NOTCH1-PI3K-mTOR-NF-κB-JMJD3-IRF4 pathway in response to Escherichia coli infection in J744A.1 cells. ARCH MICROBIOL. 2024 Jun;206(6):1-11} {WB} {Mouse}
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KDM6B Rabbit pAb(bs-20004R)-50ul/100ul/200ul
￥1180 - 2800
