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Sodium hydrogen exchanger 1 Ra

bbit pAb(bs-0505R)-50ul/100ul/200ul
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  • ￥1180 - 2800
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  • bs-0505R
  • 2025年10月16日
  • 产品信息以Bioss网站为准
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      50ul/100ul/200ul

    规格：50ul产品价格：￥1180.0
    规格：100ul产品价格：￥1980.0
    规格：200ul产品价格：￥2800.0
    产品编号bs-0505R
    英文名称Sodium hydrogen exchanger 1 Rabbit pAb
    中文名称钠氢通道蛋白抗体
    英文别名amiloride-sensitive; APNH; APNH1; FLJ42224; Na Li countertransporter; Na(+)/H(+) antiporter; Na(+)/H(+) exchanger 1; Na+H+antiporter amiloride-sensitive; Na+H+antiporter; Na+H+exchanger 1; NHE-1; NHE1; OTTHUMP00000004468; SL9A1_HUMAN; SLC9A1; Sodium hydrogen exchanger 1; Sodium/hydrogen exchanger 1; solute carrier family 9; Solute carrier family 9 member 1; Solute carrier family 9 sodium hydrogen exchanger isoform 1 antiporter Na+H+amiloride sensitive; Solute carrier family 9 subfamily A(NHE1 cation proton antiporter 1) member 1; Solute carrier family 9 subfamily A member 1.
    产品应用WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应Human, Mouse, Rat (Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep)
    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human NHE1
    亚型IgG
    性状Liquid
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    理论分子量91 kDa
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cardiovascular > Atherosclerosis > Hypertension > Sodium/ion transport

    Metabolism > Types of disease > Cancer

    Metabolism > Types of disease > Heart disease

    Signal Transduction > Adapters > Transmembrane

    Signal Transduction > Metabolism > Plasma Membrane > Channels

    亚基Oligomer. Interacts with calmodulin and TESC. Interacts (via the juxtamembrane region of the cytoplasmic C-terminus domain) with CHP1; the interaction occurs at the plasma membrane in a calcium-dependent manner. Interacts with CHP2; the interaction occurs in a calcium-dependent manner.
    亚细胞定位Membrane; Multi-pass membrane protein.
    组织特异性Kidney and intestine.
    翻译后修饰O-glycosylated.
    Ubiquitinated, leading to its degradation by the proteasome. Ubiquitination is reduced by CHP1.
    相似性Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
    功能Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料This gene encodes a Na+/H+ antiporter that is a member of the solute carrier family 9. The encoded protein is a plasma membrane transporter that is expressed in the kidney and intestine. This protein plays a central role in regulating pH homeostasis, cell migration and cell volume. This protein may also be involved in tumor growth. [provided by RefSeq, Sep 2011]

     

    应用推荐稀释比例
    {WB}{1:500-2000}
    {IHC-P}{1:100-500}
    {IHC-F}{1:100-500}
    {IF}{1:100-500}

     

    产品细节图片1
    Sample:
    Brain(Rat) lysate at 30ug;
    Liver(Rat) lysate at 30ug;
    Primary: Anti-NHE1 (bs-0505R) at 1:200 dilution;
    Secondary: HRP conjugated Goat-Anti-Rabbit IgG(bse-0295G) at 1: 3000 dilution;
    Predicted band size : 91kD
    Observed band size : 91kD
    We are unsure as to the identity of these extra bands
    产品细节图片2
    Sample:
    molt-4(human)cell Lysate at 40 ug
    Primary: Anti- Sodium hydrogen exchanger 1 (bs-0505R) at 1/300 dilution
    Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    Predicted band size: 91kD
    Observed band size: 91 kD
    产品细节图片3
    P‌‌araformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Sodium hydrogen exchanger 1) Polyclonal Antibody, Unconjugated (bs-0505R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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    该产品被引用文献

    [IF={{ 7.675 }}] {Ya-Ling Yin. et al. Citronellal Attenuates Oxidative Stress–Induced Mitochondrial Damage through TRPM2/NHE1 Pathway and Effectively Inhibits Endothelial Dysfunction in Type 2 Diabetes Mellitus. ANTIOXIDANTS-BASEL. 2022 Nov;11(11):2241} {IHC,IF} {Rat, Human}

    [IF={{ 5.714 }}] {Yaling Yin. et al. PAE ameliorates doxorubicin-induced cardiotoxicity via suppressing NHE1 phosphorylation and stimulating PI3K/AKT phosphorylation. INT IMMUNOPHARMACOL. 2022 Dec;113:109274} {IHC} {Rat}

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    文献支持
    Sodium hydrogen exchanger 1 Rabbit pAb(bs-0505R)-50ul/100ul/200ul
    ￥1180 - 2800