Sample: Kidney (Mouse) Lysate at 40 ug
Primary: Anti-Renalase (bs-7693R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 36 kD
Observed band size: 35 kD
- ￥1180 - 2800
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- bs-7693R
- 2025年10月16日
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50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-7693R |
| 英文名称 | Renalase Rabbit pAb |
| 中文名称 | 肾胺酶抗体 |
| 英文别名 | C10orf59; Chromosome 10 open reading frame 59; FLJ11218; Hypothetical protein LOC55328; MAO C; Monoamine oxidase C; RENALASE; Renalase, FAD dependent amine oxidase; RNLS antibody; RNLS_HUMAN. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 交叉反应 | Human, Mouse (Rat, Dog, Pig, Horse, Rabbit) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human Renalase |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 36 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cardiovascular > Blood > Blood Pressure regulation Cardiovascular > Heart > Contractility > Inotropics Neuroscience > Neurotransmitter > Biogenic Amines > Adrenaline Neuroscience > Neurotransmitter > Biogenic Amines > Dopamine Neuroscience > Neurotransmitter > Biogenic Amines > Noradrenaline |
| 亚细胞定位 | Secreted. |
| 组织特异性 | Secreted into the blood by the kidney. Highly expressed in the kidney, expressed at lower level in heart, skeletal muscle and small intestine. Its plasma concentration is markedly reduced in patients with end-stage renal disease, as compared with healthy subjects. |
| 相似性 | Belongs to the renalase family. |
| 功能 | Probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood and modulates cardiac function and systemic blood pressure. Degrades catecholamines such as dopamine, norepinephrine and epinephrine in vitro. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis (By similarity). According to PubMed:17385068, is unlikely that renalase has physiologically relevant catecholamine-oxidizing activity. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Renalase, a novel FAD dependent amine oxidase, is secreted by the kidney, degrades circulating catecholamines, and modulates cardiac function and lowers systemic blood pressure. In vivo, it has been found to decrease cardiac contractility and heart rate and prevents a compensatory increase in peripheral vascular tone, possibly explaining the association between increased plasma catecholamines and heightened cardiovascular risk. The plasma concentration of renalase is markedly reduced in patients with end-stage renal disease, as compared with healthy subjects. The administration of renalase (or renalase mimics) may offer a new approach to the treatment of hypertension commonly found in renal disease, which is associated with a marked increase in cardiovascular disease. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
Sample: U937 Cell (Human) Lysate at 40 ug
Primary: Anti-Renalase (bs-7693R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 36 kD
Observed band size: 36 kD
Primary: Anti-Renalase (bs-7693R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 36 kD
Observed band size: 36 kD
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Renalase Rabbit pAb(bs-7693R)-50ul/100ul/200ul
￥1180 - 2800
