Sample:
DU145 (Human)Cell Lysate at 40 ug
A549 (Human) Cell Lysate at 40 ug
Primary: Anti-CRMP3(bs-11821R)at 1/300 dilution
Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution
Predicted band size: 62kD
Observed band size: 62kD
- ￥1180 - 2800
- Bioss
- bs-11821R
- 2025年10月16日
- 产品信息以Bioss网站为准
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- 规格：
50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-11821R |
| 英文名称 | CRMP3 Rabbit pAb |
| 中文名称 | 二氢嘧啶酶相关蛋白3抗体 |
| 英文别名 | Collapsin response mediator protein 3; CRMP 3; CRMP-3; CRMP3; Dihydropyrimidinase like 4; Dihydropyrimidinase related protein 4; Dihydropyrimidinase-related protein 4; DPYL4_HUMAN; DPYSL4; DRP 4; DRP-4; DRP4; ULIP 4; ULIP-4; ULIP4; UNC33 like phosphoprotein 4; UNC33-like phosphoprotein 4. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 交叉反应 | Human, Mouse (Rat, Cow) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human CRMP3 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 62 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Neuroscience > Neurology process > Neurogenesis Neuroscience > Neurology process > Neuroregeneration > Neuroregeneration |
| 亚细胞定位 | Cytoplasm. |
| 组织特异性 | Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily. |
| 翻译后修饰 | Phosphorylated upon DNA damage, probably by ATM or ATR. |
| 相似性 | Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily. |
| 功能 | Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Collapsin response mediator proteins (CRMPs), including CRMP-1 (DRP-1), CRMP-2 (DRP-2 or TOAD64), CRMP-3 (DRP-4), CRMP-4 (DRP-3) and CRMP-5 (DRP-5), mediate signal transduction after exposure of neural cells to the axon guidance molecule Semaphorin 3A (SEMA3A)/collapsin. CRMPs are present in the developing cerebral cortex and neocortical neurons and are responsive to SEMA3A. In the adult brain, the expression of CRMPs is dramatically downregulated. However, they remain expressed in structures that retain their capacity for differentiation and plasticity. CRMP-3 is expressed transiently in developing spinal cord and selectively in the postnatal cerebellum. It is cleaved by Calpain to produce a p54 N-terminal fragment. This cleavage product translocates to the nucleus and induces neuronal death in response to excitotoxicity and cerebral ischemia. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
Sample:
Ovary(Mouse)Lysate at 40 ug
Cerebrum (Mouse)Lysate at 40 ug
Primary: Anti-CRMP3(bs-11821R)at 1/300 dilution
Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution
Predicted band size: 62kD
Observed band size: 62kD
Ovary(Mouse)Lysate at 40 ug
Cerebrum (Mouse)Lysate at 40 ug
Primary: Anti-CRMP3(bs-11821R)at 1/300 dilution
Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution
Predicted band size: 62kD
Observed band size: 62kD
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文献和实验该产品被引用文献
[IF={{ 3.171 }}] {Zhi-Sheng Ji. et al. Spastin interacts with collapsin response mediator protein 3 to regulate neurite growth and branching. Neural Regen Res. 2021 Apr;16(12):2549} {IP} {Rat}
[IF={{ 2.2 }}] {Zhiyao Xie. et al. The interaction between KATNA1 and CRMP3 modulates microtubule dynamics and neurite outgrowth. BIOCHEM BIOPH RES CO. 2025 Jan;:151426} {IF,WB} {Rat,Chlorocebus sabaeus,Human}
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CRMP3 Rabbit pAb(bs-11821R)-50ul/100ul/200ul
￥1180 - 2800
