Sample:
_x000D_
Muscle (Mouse) Lysate at 40 ug
_x000D_
Primary: Anti- Kv1.8 (bs-16866R) at 1/1000 dilution
_x000D_
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
_x000D_
Predicted band size: 58 kD
_x000D_
Observed band size: 58 kD
_x000D_
- ￥1180 - 2800
- Bioss
- bs-16866R
- 2026年10月13日
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- 技术资料
- 规格：
50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-16866R |
| 英文名称 | Kv1.8 Rabbit pAb |
| 中文名称 | 电压门控钾通道Kv1.8抗体 |
| 英文别名 | Cyclic GMP gated potassium channel; KCA10_HUMAN; Kcn 1; Kcn1; KCNA 10; KCNA10; Kv1.8; Potassium voltage gated channel shaker related subfamily member 10; Potassium voltage gated channel subfamily A member 10; Potassium voltage-gated channel subfamily A member 10; Voltage gated potassium channel subunit Kv1.8; Voltage-gated potassium channel subunit Kv1.8. |
| 产品应用 | WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500 Not yet tested in other applications. |
| 交叉反应 | Human, Mouse, Rat (Chicken, Dog, Pig, Rabbit) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human Kv1.8 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 58 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 亚基 | Homotetramer. Interacts with KCN4B/POMP. Interaction with KCN4B/POMP is necessary for the modulation of channel activity by cAMP. |
| 亚细胞定位 | Membrane. |
| 组织特异性 | Detected in kidney, in proximal tubules, glomerular endothelium, in vascular endothelium and in smooth muscle cells. |
| 相似性 | Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.8/KCNA10 sub-subfamily. |
| 功能 | Mediates voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. The channel activity is up-regulated by cAMP. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It is specifically regulated by cGMP and postulated to mediate the effects of substances that increase intracellular cGMP. This gene is intronless, and the gene is clustered with genes KCNA2 and KCNA3 on chromosome 1. [provided by RefSeq, Jul 2008] |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {IF} | {1:100-500} |
Sample:
_x000D_ Stomach (Mouse) Lysate at 40 ug
_x000D_ Primary: Anti- Kv1.8 (bs-16866R) at 1/1000 dilution
_x000D_ Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
_x000D_ Predicted band size: 58 kD
_x000D_ Observed band size: 58 kD
_x000D_
_x000D_ Stomach (Mouse) Lysate at 40 ug
_x000D_ Primary: Anti- Kv1.8 (bs-16866R) at 1/1000 dilution
_x000D_ Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
_x000D_ Predicted band size: 58 kD
_x000D_ Observed band size: 58 kD
_x000D_
Tissue/cell: human lung carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded;
_x000D_ Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
_x000D_ Incubation: Anti-Kv1.8 Polyclonal Antibody, Unconjugated(bs-16866R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
_x000D_
_x000D_ Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
_x000D_ Incubation: Anti-Kv1.8 Polyclonal Antibody, Unconjugated(bs-16866R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
_x000D_
Protein:
_x000D_ stomach(mouse) lysates at 40ug;
_x000D_ kidney (mouse) lysates at 40ug;
_x000D_ Primary: Anti-Kv1.8 (bs-16866R) at 1:300;
_x000D_ Secondary: HRP conjugated Goat-Anti-Rabbit IgG(bs-0295G-HRP) at 1: 5000;
_x000D_ ECL excitated the fluorescence;
_x000D_ Predicted band size :58 kD
_x000D_ Observed band size :58 kD
_x000D_
_x000D_ stomach(mouse) lysates at 40ug;
_x000D_ kidney (mouse) lysates at 40ug;
_x000D_ Primary: Anti-Kv1.8 (bs-16866R) at 1:300;
_x000D_ Secondary: HRP conjugated Goat-Anti-Rabbit IgG(bs-0295G-HRP) at 1: 5000;
_x000D_ ECL excitated the fluorescence;
_x000D_ Predicted band size :58 kD
_x000D_ Observed band size :58 kD
_x000D_
Tissue/cell: rat kidney tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
_x000D_ Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
_x000D_ Incubation: Anti-Kv1.8 Polyclonal Antibody, Unconjugated(bs-16866R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
_x000D_
_x000D_ Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
_x000D_ Incubation: Anti-Kv1.8 Polyclonal Antibody, Unconjugated(bs-16866R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
_x000D_
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KCNA10 | Kv1.8 Rabbit pAb(bs-16866R)-50ul/100ul/200ul
￥1180 - 2800
