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| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-8766R |
| 英文名称 | HAVCR2/TIM-3 Rabbit pAb |
| 中文名称 | T淋巴细胞膜蛋白3（CD366）抗体 |
| 英文别名 | Hepatitis A virus cellular receptor 2 homolog; CD366; CD 366; TIM-3; HAVR2_MOUSE; Kidney injury molecule 3; KIM 3; KIM3; T cell immunoglobulin and mucin domain containing 3; T cell immunoglobulin mucin 3; T-cell immunoglobulin and mucin domain-containing protein 3; T-cell immunoglobulin mucin receptor 3; T-cell membrane protein 3; TIM3; TIMD-3; TIM 3; TIMD3. |
| 产品应用 | WB=1:500-2000, ELISA=1:5000-10000 Not yet tested in other applications. |
| 交叉反应 | Mouse (Human) |
| 抗体来源 | Rabbit |
| 免疫原 | Recombinant human TIM-3 protein |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 29 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Immunology > Immunoglobulins > Receptors Immunology > Innate Immunity > Macrophage / Inflamm. |
| 亚细胞定位 | Membrane. |
| 组织特异性 | T-helper type 1 lymphocyte (Th1)-specific. |
| 翻译后修饰 | O-glycosylated with core 1 or possibly core 8 glycans. |
| 相似性 | Belongs to the immunoglobulin superfamily. TIM family. Contains 1 Ig-like V-type (immunoglobulin-like) domain. |
| 功能 | Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011] |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
| {ELISA} | {1:5000-10000} |
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文献和实验[IF={{ 6.8 }}] {Qiong Ning. et al. Tim-3 facilitates immune escape in benzene-induced acute myeloid leukemia mouse model by promoting macrophage M2 polarization. ECOTOX ENVIRON SAFE. 2023 Nov;266:115532} {IF} {Mouse}
[IF={{ 4.068 }}] {Li Wang. et al. Radiotherapy upregulated immune checkpoints contribute to the development of second primary OSCC. ORAL DIS. 2023 May;:} {WB} {Rat}
[IF={{ 3.743 }}] {Zhu G et al. ShenQi FuZheng Injection ameliorates fatigue-like behavior in mouse models of cancer-related fatigue. Biomed Pharmacother. 2019 Mar;111:1376-1382.} {IHC} {Mouse}
[IF={{ 3.542 }}] {Guo Y et al. Tim-3 exacerbates kidney ischaemia/reperfusion injury through the TLR-4/NF-κB signalling pathway and an NLR-C4 inflammasome activation. Clinical & Experimental Immunology,2018 193(1), 113–129.} {IF} {Mouse}
[IF={{ 19 }}] {Bingchen Zhang. et al. Precise RNA Editing: Cascade Self-Uncloaking Dual-Prodrug Nanoassemblies Based on CRISPR/Cas13a for Pleiotropic Immunotherapy of PD-L1-Resistant Colorectal Cancer. ADV FUNCT MATER. 2023 Sep;:2305630} {WB} {Mouse}
-bin/carddisp.pl?gene=HAVCR2&keywords=CD366 TIM3作为重要的细胞免疫负调控因子，高表达于辅助型T细胞（Thl细胞）和细胞毒性T细胞中（Tcl细胞），并产生抑制信号从而导致Thl细胞和Tcl细胞的凋亡。其配体为半乳凝素9(Gal-9)，这是一种被广泛表达的可溶性分子[7]，与TIM3分子的免疫球蛋白可变区上的寡聚糖结合，从而对Thl驱动的免疫反应产生负调控作用。当TIM3与其配体半乳凝素9(Gal-9)结合后，促进Thl细胞凋亡[8] 。也就是说
= NAL), appears to form upon oxidative cyclization of the nonfluorescent 2:1 lysine-HNE Michael adduct-Schiff base cross-link (Scheme 1). Polyclonal antibody (PAb) to the NAL-HNE fluorophore was raised in rabbit and found to be highly specific
. Retrieved 2010-11-29. ^ Nielsen BS, Jørgensen S, Fog JU, Søkilde R, Christensen IJ, Hansen U, Brünner N, Baker A, Møller S, Nielsen HJ (October 2010). "High levels of microRNA-21 in the stroma of colorectal cancers predict short disease-free survival
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