Sample:
Lane 1: Recombinant human UMOD protein, N-His
Primary: Anti-UMOD (bs-2189R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 69 kDa
Observed band size: 37 kDa
- ￥1180 - 2800
- Bioss
- bs-2189R
- 2025年10月24日
- 产品信息以Bioss网站为准
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- 规格：
50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-2189R |
| 英文名称 | UMOD Rabbit pAb |
| 中文名称 | 尿调节蛋白抗体 |
| 英文别名 | Uromucoid; ADMCKD2; FJHN; HNFJ; HNFJ1; MCKD2; medullary cystic kidney disease 2(autosomal dominant); Tamm Horsfall glycoprotein; Tamm Horsfall urinary glycoprotein; Tamm-Horsfall urinary glycoprotein; THGP; THP; Umod; UROM_MOUSE; uromodulin(uromucoid, Tamm-Horsfall glycoprotein); Uromodulin; Uromodulin, secreted form. |
| 产品应用 | WB=1:500-2000, IHC-P=1:400-800, IHC-F=1:400-800, IF=1:100-500 Not yet tested in other applications. |
| 交叉反应 | Human, Mouse, Rat |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from mouse UMOD |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 61/65 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cell Biology > Other Antibodies > Other Antibodies |
| 亚细胞定位 | Apical cell membrane; Lipid-anchor, GPI-anchor (By similarity). Basolateral cell membrane; Lipid-anchor, GPI-anchor (By similarity). Cell projection, cilium membrane (By similarity). Note=Only a small fraction is sorts to the basolateral pole of tubular epithelial cells compared to apical localization (By similarity). Uromodulin, secreted form: Secreted (By similarity). |
| 组织特异性 | Synthesized exclusively in the kidney.Expressed exclusively by epithelial cells of the thick ascendinglimb of Henle's loop (TALH) and of distal convoluted tubule lumen.Most abundant protein in normal urine. |
| 翻译后修饰 | N-glycosylated. |
| 相似性 | Contains 3 EGF-like domains.
Contains 1 ZP domain. |
| 功能 | Uromodulin: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure providing the water barrier permeability. May serve as a receptor for binding and endocytosis for cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelial (By similarity). Uromodulin, secreted form: Secreted into urine after proteolytically cleaveage. Into the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes, prevents urinary tract infection and modulates formation of supersaturated salts and their crystals. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is the most abundant protein in mammalian urine under physiological conditions. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. This protein may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of this protein in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the renal disorders medullary cystic kidney disease-2 (MCKD2), glomerulocystic kidney disease with hyperuricemia and isosthenuria (GCKDHI), and familial juvenile hyperuricemic nephropathy (FJHN). Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2013]. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
| {IHC-P} | {1:400-800} |
| {IHC-F} | {1:400-800} |
| {IF} | {1:100-500} |
Paraformaldehyde-fixed, paraffin embedded Rat Kidney; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with UMOD Polyclonal Antibody, Unconjugated (bs-2189R) at 1:200 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
Paraformaldehyde-fixed, paraffin embedded Mouse Kidney; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with UMOD Polyclonal Antibody, Unconjugated (bs-2189R) at 1:200 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
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文献和实验该产品被引用文献
[IF={{ 5.4 }}] {Francesca Giannuzzi. et al.Unveiling spontaneous renal tubule-like structures from human adult renal progenitor cell spheroids derived from urine..Stem Cells Translational Medicine.2025 Mar 18;14(3):szaf002.} {IF} {Human}
[IF={{ 1.679 }}] {Kim et al. Blocking junctional adhesion molecule C promotes the recovery of cisplatin-induced acute kidney injury. (2017) Korean.J.Intern.Me. 32:1053-1061} {FCM} {Mouse}
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UMOD Rabbit pAb(bs-2189R)-50ul/100ul/200ul
￥1180 - 2800
