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- bs-2411R
- 2025年10月24日
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| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-2411R |
| 英文名称 | NKG2A Rabbit pAb |
| 中文名称 | NK细胞受体2A抗体 |
| 英文别名 | KLRC1; C lectin type II protein; CD159 antigen like family member A; CD159A; Killer cell lectin like receptor subfamily C member 1; MGC13374; MGC59791; Natural killer cell lectin; Natural killer group protein 2; NK cell receptor A; NKG2 1/B activating NK receptor; NKG2 A/B activating NK receptor; NKG2 A/B type II integral membrane protein; NKG2; NKG2A_HUMAN; NKG2-A/NKG2-B type II integral membrane protein; NKG2-A/B-activating NK receptor. |
| 产品应用 | IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500, ELISA=1:5000-10000 Not yet tested in other applications. |
| 交叉反应 | (Mouse, Rat) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from mouse NKG2A |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 28 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Immunology > Cell Type Markers > CD > NK Cells |
| 亚基 | Can form disulfide-bonded heterodimer with CD94. |
| 亚细胞定位 | Membrane; Single-pass type II membrane protein. |
| 组织特异性 | Natural killer cells. |
| 相似性 | Contains 1 C-type lectin domain. |
| 功能 | Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed. [provided by RefSeq, Jul 2008] |
| 应用 | 推荐稀释比例 |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {IF} | {1:100-500} |
| {ELISA} | {1:5000-10000} |
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文献和实验[IF={{ preprint }}] {Felicia Lazure. et al.Aging directs the differential evolution of KRAS-driven lung adenocarcinoma.biorxiv.2025 Jan 24:2025.01.20.633951.} {IF} {Mouse}
[IF={{ 6.1 }}] {Hall, L. J., et al. "Natural killer cells protect mice from DSS-induced colitis by regulating neutrophil function via the NKG2A receptor." Mucosal Immunology 6.5 (2013): 1016-1026.} {Other} {="Mouse"}
[IF={{ 2.37 }}] {Zou, Z., et al. "The ANXA1 released from intestinal epithelial cells alleviate DSS-induced colitis by improving NKG2A expression of Natural Killer cells."Biochemical and Biophysical Research Communications (2016).} {Other} {="Mouse"}
[IF={{ 15.304 }}] {Yao Lei. et al. Phytochemical natural killer cells reprogram tumor microenvironment for potent immunotherapy of solid tumors. BIOMATERIALS. 2022 Jun;:121635} {WB,IF,FCM} {Mouse}
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