- ￥1180 - 2800
- Bioss
- bs-1973R
- 2025年10月24日
- 产品信息以Bioss网站为准
企业认证
相关产品推荐更多 >
CAPD2 Rabbit pAb(bs-7718R)-50ul/100ul/200ul
￥1180
phospho-VEGFR2 (Tyr1175) Rabbit pAb, Cy5.5 conjugated(bs-3468R-Cy5.5)-100ul
￥2980
Caspase-1 p20 Rabbit pAb, FITC conjugated(bs-10743R-FITC)-100ul
￥2980MLCK Rabbit pAb, APC conjugated(bs-4705R-APC)-100ul
￥2980
PAR4 Rabbit pAb(bs-9511R)-50ul/100ul/200ul
￥1180
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 应用范围：
产品信息以Bioss网站为准
- 规格：
50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-1973R |
| 英文名称 | Lipoprotein lipase Rabbit pAb |
| 中文名称 | 脂蛋白脂酶抗体 |
| 英文别名 | Lipoprotein lipase; LIPD; LIPL_HUMAN; LPL; LPL protein; EC 3.1.1; EC 3.1.1.34; HDLCQ11; LPL; LPL protein; MGC137861. |
| 产品应用 | WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500, Flow-Cyt=0.2μg /test Not yet tested in other applications. |
| 交叉反应 | Human, Mouse, Rat (Pig, Cow, Rabbit, Sheep, GuineaPig) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human LPL |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 52 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Cancer Metabolism > Metabolic signaling pathway > Metabolism of lipids and lipoproteins Cardiovascular > Lipids / Lipoproteins > Lipid Metabolism > Lipases Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Lipases Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Lipid metabolism Metabolism > Types of disease > Cancer Metabolism > Types of disease > Obesity Signal Transduction > Metabolism > Lipid metabolism Stem Cells > Mesenchymal Stem Cells > Adipogenesis |
| 亚基 | Homodimer. Interacts with APOC2; the interaction activates LPL activity in the presence of lipids. Interacts with GPIHBP1. |
| 亚细胞定位 | Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Locates to the plasma membrane of microvilli of hepatocytes with triacyl-glycerol-rich lipoproteins (TRL). Some of the bound LPL is then internalized and located inside non-coated endocytic vesicles. |
| 组织特异性 | Detected in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia, in spleen and other lymph node-containing organs. Expressed in peripheral blood T lymphocytes, neutrophils, monocytes, B lymphocytes, and myeloid cells. |
| 翻译后修饰 | Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity. |
| 相似性 | Belongs to the AB hydrolase superfamily. Lipase family. Contains 1 PLAT domain. |
| 功能 | Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Lipoprotein lipase (LPL) is the central enzyme in plasma triglyceride hydrolysis and is secreted by macrophages in the subendothelial space. Evidence has been provided that LPL produced by macrophages in the vessel wall exerts proatherogenic effects. The atherogenic effects of LPL have been mainly attributed to its ability to favor lipid accumulation within macrophages present in the atherosclerotic lesion. Recently, it has also been shown that LPL promote the development of atherosclerosis through facilitation of monocyte adhesion to endothelial cells, stimulation of tumor necrosis factor alpha (TNF ) secretion and induction of vascular smooth muscle cell proliferation. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {IF} | {1:100-500} |
| {Flow-Cyt} | {0.2μg /test} |
Primary Antibody (green line): Rabbit Anti-Lipoprotein lipase antibody (bs-1973R); Dilution: 0.2μg /10^6 cells;
Isotype Control Antibody (orange line): Rabbit IgG .
Secondary Antibody (white blue line): Goat anti-rabbit IgG-PE; Dilution: 1μg /test.
Primary: Anti-Lipoprotein lipase (bs-1973R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 52kD
Observed band size: 55kD
Lane 1: Human HeLa cell lysates
Lane 2: Human MCF-7 cell lysates
Lane 3: Human HL-60 cell lysates
Primary: Anti-Lipoprotein lipase (bs-1973R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 52 kDa
Observed band size: 60 kDa
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验[IF={{ 5.6 }}] {Yating Fan. et al. β-Sitosterol Suppresses Lipopolysaccharide-Induced Inflammation and Lipogenesis Disorder in Bovine Mammary Epithelial Cells. INT J MOL SCI. 2023 Jan;24(19):14644} {WB} {Bovine}
[IF={{ 5 }}] {Tam Nguyen. et al. Treprostinil palmitil inhalation powder leverages endogenous lung enzymes to provide sustained treprostinil. EXPERT OPIN DRUG DEL. 2024 九月 12} {WB} {Human}
[IF={{ 4.9 }}] {Yi Li. et al. Kaili sour soup in alleviation of hepatic steatosis in rats via lycopene route: an experimental study. ANN MED. 2025 四月 21} {WB} {Rat}
[IF={{ 3.616 }}] {Tan W et al. Pyrazinamide alleviates rifampin-induced steatohepatitis in mice by regulating the activities of cholesterol-activated 7α-hydroxylase and lipoprotein lipase. Eur J Pharm Sci . 2020 Aug 1;151:105402.} {WB} {Mouse}
[IF={{ 3.514 }}] {Li B et al. Resistin up-regulates LPL expression through the PPARγ-dependent PI3K/AKT signaling pathway impacting lipid accumulation in RAW264. 7 macrophages.Cytokine. 2019 Jul;119:168-174.} {WB} {Mouse}
Overview of the Measurement of Lipids and Lipoproteins in Mice
, S., Sandhofer, A., Hölzl, B., Gander, R., Ebenbichler, C.F., Paulweber, B., and Patsch, J.R. 2003. Phospholipid and cholesteryl ester transfer are increased in lipoprotein lipase deficiency. J. Intern. Med. 253:208‐216
hyperchylomicronemia）（血浆乳糜微粒增高）、家族性脂蛋白脂酶缺乏（familial lipoprotein lipase deficiency）（血浆乳糜微粒增高）、家族性高甘油三酯血症（familial hypertriglyceridemia）（血浆VLDL、乳糜微粒增高、HDL降低）及家族性联合高脂血症等。 二、动脉粥样硬化发生机制学说 动脉粥样硬化的发病机制至今尚未完全明了，主要学说有： 1．脂源性学说 此说基于高脂血症与本病的因果关系。实险研究也证明，给动物喂饲富含胆固醇和脂肪
Models and Analysis of Atherosclerosis, Restenosis, and Aneurysm Formation in the Mouse
is considered a chronic inflammatory condition of the vessel wall and involves a high chronic concentration of low?density lipoprotein (LDL) in blood. In humans, restenosis develops after intravascular interventions such as angioplasty and stent placement
技术资料暂无技术资料 索取技术资料
