CYP1A1 | AHH Rabbit pAb(bs-1606R)-50ul/100ul/200ul产品图
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CYP1A1 | AHH Rabbit pAb(bs-160

6R)-50ul/100ul/200ul
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  • ￥1180 - 2800
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  • bs-1606R
  • 2026年10月13日
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    北京博奥森生物技术有限公司
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      50ul/100ul/200ul

    规格：50ul产品价格：￥1180.0
    规格：100ul产品价格：￥1980.0
    规格：200ul产品价格：￥2800.0
    产品编号bs-1606R
    英文名称CYP1A1 Rabbit pAb
    中文名称细胞色素P450 1A1抗体
    英文别名Cytochrome p450 1A1; Cytochrome P450 form 6; Cytochrome P450-C; Cytochrome P450-P1; Hydroperoxy icosatetraenoate dehydratase; CP1A1_HUMAN
    产品应用WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应Human, Mouse, Rat (Pig)
    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human CYP1A1
    亚型IgG
    性状Liquid
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    理论分子量58 kDa
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cancer > Cancer Metabolism > Cellular metabolic process

    Cancer > Cancer Metabolism > Response to hypoxia

    Cardiovascular > Lipids / Lipoproteins > Lipid Metabolism > Cytochromes

    Metabolism > Pathways and Processes > Metabolic signaling pathways > Drug metabolism

    Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Lipases

    Metabolism > Pathways and Processes > Metabolism processes > Hypoxia

    Metabolism > Pathways and Processes > Mitochondrial Metabolism > Cytochromes

    Metabolism > Types of disease > Cancer

    Signal Transduction > Metabolism > Drug metabolism

    亚细胞定位Endoplasmic reticulum
    组织特异性Lung, lymphocytes and placenta.
    相似性Belongs to the cytochrome P450 family.
    功能Cytochrome P450 oxidase (commonly abbreviated CYP) is a generic term for a large number of related, but distinct, oxidative enzymes important in vertebrate physiology. The cytochrome P450 mixed-function monooxygenase system is probably the most important element of Phase I metabolism in mammals. P450s are membrane-bound, either in the inner membrane of mitochondria or in the endoplasmic reticulum of cells where they metabolise thousands of endogenous and exogenous compounds. In the liver, these substrates include toxins, drugs, and other unneeded and potentially harmful molecules. Humans have 18 families of cytochrome P450 genes and 43 subfamilies; the CYP1 family is involved in drug metabolism and includes 3 subfamilies, 3 genes and 1 pseudogene.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. [provided by RefSeq, Jul 2008]

     

    应用推荐稀释比例
    {WB}{1:500-2000}
    {IHC-P}{1:100-500}
    {IHC-F}{1:100-500}
    {IF}{1:100-500}

     

    产品细节图片1
    Sample:K562 Cell (Human) Lysate at 30 ug
    _x000D_ Primary: Anti- CYP1A1 (bs-1606R)at 1/300 dilution
    _x000D_ Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    _x000D_ Predicted band size: 58kD
    _x000D_ Observed band size: 58kD
    _x000D_
    产品细节图片2
    Sample:Lung (Mouse) Lysate at 40 ug
    _x000D_ Primary: Anti- CYP1A1 (bs-1606R)at 1/300 dilution
    _x000D_ Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    _x000D_ Predicted band size: 58kD
    _x000D_ Observed band size: 58kD
    _x000D_
    产品细节图片3
    P‌‌araformaldehyde-fixed, paraffin embedded (rat testis tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CYP1A1) Polyclonal Antibody, Unconjugated (bs-1606R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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    CYP1A1 | AHH Rabbit pAb(bs-1606R)-50ul/100ul/200ul
    ￥1180 - 2800