TNFSF14 | HVEML/CD258 Rabbit pAb(bs-2462R)-50ul/100ul/200ul产品图
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TNFSF14 | HVEML/CD258 Rabbit p

Ab(bs-2462R)-50ul/100ul/200ul
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  • ￥1180 - 2800
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  • 2026年10月13日
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    北京博奥森生物技术有限公司
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      50ul/100ul/200ul

    规格：50ul产品价格：￥1180.0
    规格：100ul产品价格：￥1980.0
    规格：200ul产品价格：￥2800.0
    产品编号bs-2462R
    英文名称TNFSF14 Rabbit pAb
    中文名称肿瘤坏死因子配体超家族成员14抗体
    英文别名Tumor necrosis factor ligand superfamily member 14; CD 258; CD258; CD258 antigen; delta transmembrane LIGHT; Herpes virus entry mediator ligand; Herpesvirus entry mediator A; Herpesvirus entry mediator ligand; herpesvirus entry mediator-ligand; HVEM L; HVEM-L; HVEML; Ligand for herpesvirus entry mediator; LIGHT; LTg; soluble form; TNF14; TNFSF 14; TNFSF14 protein; TR 2; TR2; Tumor necrosis factor(ligand) superfamily, member 14; Tumor necrosis factor ligand superfamily, member 14; Tumor necrosis factor receptor like 2; Tumor necrosis factor superfamily member LIGHT; TNF14_HUMAN.
    产品应用WB=1:500-2000, ELISA=1:500-5000

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应Mouse (Human, Rat)
    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human TNFSF14
    亚型IgG
    性状Liquid
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    理论分子量26 kDa
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    亚基Homotrimer.
    亚细胞定位Tumor necrosis factor ligand superfamily member 14, membrane form: Cell membrane; Single-pass type II membrane protein.
    Tumor necrosis factor ligand superfamily member 14, soluble form: Secreted.
    Isoform 2: Cytoplasm.
    组织特异性Predominantly expressed in the spleen but also found in the brain. Weakly expressed in peripheral lymphoid tissues and in heart, placenta, liver, lung, appendix, and kidney, and no expression seen in fetal tissues, endocrine glands, or nonhematopoietic tumor lines.
    翻译后修饰N-glycosylated.
    The soluble form of isoform 1 derives from the membrane form by proteolytic processing.
    相似性Belongs to the tumor necrosis factor family.
    功能Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料LIGHT protein is a type II transmembrane protein and a tumor necrosis factor (TNF) ligand superfamily member (TNFSF14). LIGHT is expressed on activated T cells and immature dendritic cells and its receptors have been identified as lymphotoxin-Beta receptor (LTBetaR) and the herpesvirus entry mediator (HVEM), both of which lack the cytoplasmic sequence termed as "death domain." LIGHT is first identified as HVEM ligand (HVEM-L) and a deterrent to herpesvirus infection according to its ability to compete with HSV glycoprotein D for HVEM binding. As a T cell-derived costimulatory ligand, TNFSF14 plays a crucial role in T cell activation and proliferation by LIGHT-LTBetaR interaction, and it is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells. Additionally, recent studies also establish a direct role for LIGHT in NK activation/expansion via LIGHT-HVEM interaction, and thus breaking T-cell tolerance at the tumor site. Accordingly, LIGHT is suggested to be involved in CTL-mediated tumor rejection, allograft rejection and graft versus host disease. Although known as lymphotoxin-Gamma, LIGHT plays a minimal role in lymphoid tissue development in contrast with LT-Alpha and Beta. This protein was also demonstrated to inhibit TNF-Alpha-mediated but not Fas- or TRAIL-mediated apoptosis of human primary hepatocytes.

     

    应用推荐稀释比例
    {WB}{1:500-2000}
    {ELISA}{1:500-5000}

     

    产品细节图片1
    Sample:
    _x000D_ Spleen (Mouse) Lysate at 40 ug
    _x000D_ Small intestine (Mouse) Lysate at 40 ug
    _x000D_ Primary: Anti-TNFSF14 (bs-2462R) at 1/1000 dilution
    _x000D_ Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    _x000D_ Predicted band size: 26 kD
    _x000D_ Observed band size: 26 kD

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    TNFSF14 | HVEML/CD258 Rabbit pAb(bs-2462R)-50ul/100ul/200ul
    ￥1180 - 2800