Sample: Brain (Mouse) Lysate at 40 ug
Primary: Anti-RUNX1T1 (bs-6101R) at 1/300 dilution
Secondary: HRP conjugated Goat-Anti-rabbit IgG (bs-0295G-HRP) at 1/5000 dilution
Predicted band size: 66 kD
Observed band size: 66 kD
- ￥1180 - 2800
- Bioss
- bs-6101R
- 2025年10月24日
- 产品信息以Bioss网站为准
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50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-6101R |
| 英文名称 | RUNX1T1 Rabbit pAb |
| 中文名称 | 周期素D相关蛋白抗体 |
| 英文别名 | Acute myelogenous leukemia 1 translocation 1 cyclin D related; Acute myelogenous leukemia 1 translocation 1 protein; AML1T1; CBFA2T1; CDR; Core binding factor runt domain alpha subunit 2 translocated to 1; Core binding factor runt domain alpha subunit 2 translocated to 1 cyclin D related; Cyclin D related; Cyclin D related protein; Eight twenty one protein; Eigth twenty one protein; ETO; ETO protein; MTG 8; MTG 8b; MTG8. MTG8 protein; MTG8b antibody Myeloid translocation gene on 8q22; Protein CBFA2T1; Protein ETO; Protein MTG 8; Protein MTG8; Runt related transcription factor 1 translocated to 1(cyclin D related); Runt related transcription factor 1 translocated to 1; Runt related transcription factor 1 translocated to 1 cyclin D related; Zinc finger MYND domain containing protein 2; ZMYND 2; ZMYND2. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 交叉反应 | Mouse (Human, Rat, Chicken, Dog, Pig, Horse, Rabbit) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human RUNX1T1/ETO |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 66 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Oncoproteins/suppressors > Tumor suppressors Epigenetics and Nuclear Signaling > Transcription > Domain Families > Zinc Finger Epigenetics and Nuclear Signaling > Transcription > Transcription Factors |
| 亚基 | Homotetramer. Heterotetramer with CBFA2T2 and CBFA2T3. Interacts with TCF12, SIN3A, HDAC1, HDAC2, HDAC3, NCOR1 and NCOR2. Interacts with ATN1 (via its N-terminus); the interaction enhances the transcriptional repression. |
| 亚细胞定位 | Nucleus. |
| 组织特异性 | Most abundantly expressed in brain. Lower levels in lung, heart, testis and ovary. |
| 相似性 | Belongs to the CBFA2T family. Contains 1 MYND-type zinc finger. Contains 1 TAFH (NHR1) domain. |
| 功能 | Homotetramer. Heterotetramer with CBFA2T2 and CBFA2T3. Interacts with TCF12, SIN3A, HDAC1, HDAC2, HDAC3, NCOR1 and NCOR2. Interacts with ATN1 (via its N-terminus); the interaction enhances the transcriptional repression. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | RUNX1T1 is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Several transcript variants encoding multiple isoforms have been found for this gene. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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RUNX1T1 Rabbit pAb(bs-6101R)-50ul/100ul/200ul
￥1180 - 2800
