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- bs-1144R
- 2025年10月24日
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| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-1144R |
| 英文名称 | TFPI-2 Rabbit pAb |
| 中文名称 | 组织因子途径抑制剂-2抗体 |
| 英文别名 | tissue factor pathway inhibitor 2; TFPI-2; TFPI2; TFPI2_HUMAN; Tissue factor pathway inhibitor 2; Placental protein 5; PP5; TFPI 2; TFPI 2; TFPI2 PEN. |
| 产品应用 | IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500 Not yet tested in other applications. |
| 交叉反应 | Human, Rat (Mouse, Cow) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human TFPI2 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 25 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cardiovascular > Blood > Coagulation > Regulatory Cardiovascular > Blood > Fibrinolysis / Thrombolysis Cell Biology > Proteolysis / Ubiquitin > Protease inhibitors > Other protease inhibitors |
| 亚细胞定位 | Secreted (constituent of proteinaceous extracellular matrix) |
| 组织特异性 | Umbilical vein endothelial cells, liver, placenta, heart, pancreas, and maternal serum at advanced pregnancy. |
| 相似性 | Contains 3 BPTI/Kunitz inhibitor domains. |
| 功能 | May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | TFPI2 may play a role in the regulation of plasmin-mediated matrix remodeling. It inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa, but it has no effect on thrombin. TFPI2 is specific to umbilical vein endothelial cells, liver, placenta, heart, pancreas, and maternal serum at advanced pregnancy. This inhibitor contains three inhibitory domains. TFPI2 contains 3 BPTI/Kunitz inhibitor domains. |
| 应用 | 推荐稀释比例 |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {IF} | {1:100-500} |
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37鈩� for 20 min;
Incubation: Anti-TFPI-2 Polyclonal Antibody, Unconjugated(bs-1144R) 1:200, overnight at 4掳C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-TFPI-2 Polyclonal Antibody, Unconjugated(bs-1144R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37鈩� for 20 min;
Incubation: Anti-TFPI-2 Polyclonal Antibody, Unconjugated(bs-1144R) 1:200, overnight at 4掳C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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文献和实验[IF={{ 4.7 }}] {Yu Xia. et al. Astilbin targeted Sirt1 to inhibit acetylation of Nrf2 to alleviate grass carp hepatocyte apoptosis caused by PCB126-induced mitochondrial kinetic and metabolism dysfunctions. FISH SHELLFISH IMMUN. 2023 Oct;141:109000} {WB} {Fish}
[IF={{ 3.8 }}] {Asayag Keren. et al. Effect of bone marrow blood versus peripheral blood on the hemostatic balance of osteoblasts and endothelial cells. SCI REP-UK. 2025 Apr;15(1):1-16} {ICC} {Human}
[IF={{ 3.491 }}] {Hussam Ghoti. et al. Heparanase Level and Procoagulant Activity Are Increased in Thalassemia and Attenuated by Janus Kinase 2 Inhibition. Am J Pathol. 2020 Oct;190:2146} {IHC} {Mouse}
[IF={{ 0.34 }}] {Wang, Gui-Jun, et al. "Expression of tissue factor pathway inhibitor-2 in gastric stromal tumor and its clinical significance." Experimental and Therapeutic Medicine.} {IHC} {="Human"}
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