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| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-1956R |
| 英文名称 | smooth muscle Myosin heavy chain 11 Rabbit pAb |
| 中文名称 | 平滑肌肌球蛋白重链抗体 |
| 英文别名 | SMMHC; Myosin 11; Myosin-11; Myosin, smooth muscle, heavy chain; Myosin Smooth Muscle; AAT 4; AAT4; DKFZp686D10126; DKFZp686D19237; FAA 4; FAA4; FLJ35232; KIAA0866; MGC126726; MGC32963; MYH 11; MYH11 protein; Myosin heavy chain 11 smooth muscle; Myosin heavy chain smooth muscle isoform; Myosin heavy polypeptide 11 smooth muscle; Myosin11; SMHC; Smooth muscle myosin heavy chain isoform SM1; MYH11_HUMAN. |
| 产品应用 | IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500, ELISA=1:5000-10000 Not yet tested in other applications. |
| 交叉反应 | (Human, Mouse, Rat, Dog, Cow) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human SMHC |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 227 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cardiovascular > Cardiovascular Markers > Cell Markers > Smooth Muscle Cells Cardiovascular > Heart > Contractility > Contractile Proteins > Myosins Signal Transduction > Cytoskeleton / ECM > Cytoskeleton > Motor Proteins > Myosin |
| 亚基 | Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). |
| 亚细胞定位 | Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Thick filaments of the myofibrils. |
| 组织特异性 | Smooth muscle; expressed in the umbilical artery, bladder, esophagus and trachea. |
| 相似性 | Contains 1 IQ domain. Contains 1 myosin head-like domain. |
| 功能 | Muscle contraction. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. The pericentric inversion of chromosome 16[inv(16)(p13q22)] produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation. Alternatively spliced transcript variants encoding different isoforms have been identified.MYH11 is a smooth muscle myosin belonging to the myosin heavy chain family. It is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. |
| 应用 | 推荐稀释比例 |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {IF} | {1:100-500} |
| {ELISA} | {1:5000-10000} |
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文献和实验[IF={{ 4.222 }}] {Yi Song. et al. LncRNA SENCR overexpression attenuated the proliferation, migration and phenotypic switching of vascular smooth muscle cells in aortic dissection via the miR-206/myocardin axis. Nutr Metab Cardiovas. 2022 Mar;:} {IHC} {Other}
[IF={{ 2.76 }}] {Liu, Guanghui, et al. "Isolation, purification, and cultivation of primary retinal microvascular pericytes: a novel model using rats." Microcirculation (2014).} {Other} {="Rat"}
[IF={{ 1.977 }}] {Jie Li. et al. MicroRNA-127-3p regulates myoblast proliferation by targeting Sept7. Biotechnol Lett. 2020 Sep;42(9):1633-1644} {WB} {Mouse}
Isolation and Culture of Human Airway Smooth Muscle Cells
doublings and express smooth muscle cell-specific markers such as myosin heavy chain, myosin light chain kinase, α-actin, caldesmon, and SM22α . In addition, the synthetic function of these cells appears to be comparable to those studied in vivo
The immunoglobulins secreted by plasma cells are four-chain molecules with two heavy and two light chains. Each chain has a variable (V) region and one or more constant (C) regions, which are coded by separate genes. The V regions of both light and heavy chains
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