Sample:
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Lane 1: Human HeLa cell lysates
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Lane 2: Human HepG2 cell lysates
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Lane 3: Human A431 cell lysates
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Primary: Anti-Complement C2 (bs-8613R) at 1/1000 dilution
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Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
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Predicted band size: 57/81 kDa
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Observed band size: 87 kDa
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- ￥1180 - 2800
- Bioss
- bs-8613R
- 2026年10月13日
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50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-8613R |
| 英文名称 | Complement C2 Rabbit pAb |
| 中文名称 | 补体C2抗体 |
| 英文别名 | Complement C2; Complement component 2; Complement factor 2; Complement C2a fragment; CO2_HUMAN. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 交叉反应 | Human (Mouse, Rat, Dog, Pig, Horse) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human Complement C2/Complement C2a fragment |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 57/81 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Immunology > Innate Immunity > Complement > Classical Pathway |
| 亚基 | C2a interacts with Schistosoma haematobium TOR (viaN-terminal extracellular domain). This results in inhibition of theclassical and lectin pathway of complement activation, probably dueto interference with binding of C2a to C4b such that C3 convertasecannot be formed. This infers resistance to complement-mediatedcell lysis, allowing parasite survival and infection. |
| 亚细胞定位 | Secreted. |
| 相似性 | Belongs to the peptidase S1 family._x000D_
Contains 1 peptidase S1 domain._x000D_ Contains 3 Sushi (CCP/SCR) domains._x000D_ Contains 1 VWFA domain. |
| 功能 | Component C2 which is part of the classical pathway ofthe complement system is cleaved by activated factor C1 into twofragments: C2b and C2a. C2a, a serine protease, then combines withcomplement factor 4b to generate the C3 or C5 convertase. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | bs-10482P is one synthetic peptide derived from human C2a. Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.[provided by RefSeq, Mar 2009]. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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文献和实验相关实验
)测试中，其变化规律与补体的变化趋势有显著的相关性(C3、C4与IgGr=0.6683；0.6439；与IgM r=0.5805；0.6296；与IgA r=0.7569；0.9302)。表明补体水平的变化与抗体的变化直接有关。 （3）运动时内环境理化因素的改变：补体系统存在经典激活途径与旁路激活途径。补体一旦被激活后，被激活的裂解产物会产生酶样作用，依次激活下一补体，即逐步由识别阶段(C1q，C1r及C1s)过渡到效应阶段(C2、C3、C4、C5)与膜攻击阶段(C6-C9)。而由于运动中大量消耗
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C2 | Complement C2 Rabbit pAb(bs-8613R)-50ul/100ul/200ul
￥1180 - 2800
