Capn2 | Calpain-2 Rabbit pAb(bs-1599R)-50ul/100ul/200ul产品图
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Capn2 | Calpain-2 Rabbit pAb(b

s-1599R)-50ul/100ul/200ul
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  • ￥1180 - 2800
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  • bs-1599R
  • 2026年10月13日
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    北京博奥森生物技术有限公司
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      50ul/100ul/200ul

    规格：50ul产品价格：￥1180.0
    规格：100ul产品价格：￥1980.0
    规格：200ul产品价格：￥2800.0
    产品编号bs-1599R
    英文名称Calpain 2 Rabbit pAb
    中文名称钙激活的中性蛋白酶2抗体
    英文别名Calcium activated neutral proteinase 2; Calcium activated neutral proteinase; CALP80; Calpain 2(m/II) large subunit; Calpain 2 catalytic subunit; Calpain 2 large catalytic subunit; Calpain 2 large subunit; Calpain large polypeptide L2; Calpain M type; Calcium-activated neutral proteinase 2; CALP80; Calpain 2, large [catalytic] subunit; Calpain M-type; Calpain-2 catalytic subunit; Calpain-2 large subunit; CAN2_MOUSE; M-calpain; Millimolar-calpain; Calpain2; CANP 2; CANP L2; CANP2; CANPL 2; CANPL2; CANPml; Capa2; CAPN 2; CAPN2; FLJ39928; M calpain; M calpin; M type; mCANP; Millimolar calpain.
    产品应用WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应Human, Mouse (Rat, Dog, Cow, Sheep)
    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from mouse Calpain 2
    亚型IgG
    性状Liquid
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    理论分子量78 kDa
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cancer > Cancer Metabolism > Response to hypoxia

    Cell Biology > Proteolysis / Ubiquitin > Proteolytic enzymes > Cysteine protease > Calpains

    Metabolism > Pathways and Processes > Metabolism processes > Hypoxia

    Metabolism > Types of disease > Cancer

    Signal Transduction > Signaling Pathway > Calcium Signaling > Calpain

    亚基Forms a heterodimer with a small (regulatory) subunit (CAPNS1).
    亚细胞定位Cytoplasm. Cell membrane. Note=Translocates to the plasma membrane upon Ca(2+) binding.
    组织特异性Ubiquitous.
    相似性Belongs to the peptidase C2 family.
    Contains 1 calpain catalytic domain.
    Contains 2 EF-hand domains.
    功能Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Calpain, and m calpain, also known as Calpain 2, are intracellular, calcium dependent cysteine proteases. Mu calpain has a micromolar sensitivity (thus the mu) as compared to the millimolar calcium sensitivity of m calpain. Both Calpains 1 and 2 are composed of an 80 kD subunit and a 30 kD subunit. Whereas the 30 kDa subunit is shared by both enzymes, the larger catalytic subunits are different and exhibit the distinct Ca++ requirements that are suggested by their names. The calpains have papain like activity, thus the pain nomenclature. Both Calpain 1 and Calpain 2 are ubiquitously expressed, and are countered by the endogenous calpain inhibitor, calpastatin. Other calpain family members (calpain 94, ncl2, ncl3, etc) have more limited tissue distribution, and perhaps different functions. The calpain family members consist of a common small subunit (Calpain 4), and a large variable subunit. It is not clear that all calpains contain a small subunit. Domains in the large subunit include the amino terminal domain I, the proteinase domain II, domain III, and the EF hand domain IV. The calpains appear to serve multiple physiological roles, and ideas concerning the functions of these enzymes are in a state of rapid flux.

     

    应用推荐稀释比例
    {WB}{1:500-2000}
    {IHC-P}{1:100-500}
    {IHC-F}{1:100-500}
    {IF}{1:100-500}

     

    产品细节图片1
    P‌‌araformaldehyde-fixed, paraffin embedded (human breast carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Calpain 2) Polyclonal Antibody, Unconjugated (bs-1599R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
    产品细节图片2
    Sample:
    _x000D_ Brain (Mouse) Lysate at 40 ug
    _x000D_ Primary: Anti- Calpain 2(bs-1599R) at 1/300 dilution
    _x000D_ Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    _x000D_ Predicted band size: 78 kD
    _x000D_ Observed band size: 90 kD
    产品细节图片3
    Sample:
    _x000D_ NIH/3T3(Mouse) Cell Lysate at 30 ug
    _x000D_ Primary: Anti-Calpain 2 (bs-1599R) at 1/1000 dilution
    _x000D_ Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    _x000D_ Predicted band size: 78 kD
    _x000D_ Observed band size: 78 kD

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    图标文献和实验
    该产品被引用文献

    [IF=6.064] Mengni Bao. et al. N-Acetylcysteine, an ROS Inhibitor, Alleviates the Pathophysiology of Hyperthyroidism-Induced Cardiomyopathy via the ROS/Ca2+ Pathway. BIOMOLECULES. 2022 Sep;12(9):1195 WB Mouse,Rat

    [IF=2.9] Xiaoyue Guan. et al. Ginsenoside Rb1 ameliorates apical periodontitis via suppressing macrophage pyroptosis. ORAL DIS. 2024 Aug;: IHC,IF,WB Human

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    Capn2 | Calpain-2 Rabbit pAb(bs-1599R)-50ul/100ul/200ul
    ￥1180 - 2800