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- 2025年10月24日
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50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-2475R |
| 英文名称 | CCL4 Rabbit pAb |
| 中文名称 | 巨噬细胞炎性蛋白1β抗体 |
| 英文别名 | MIP-1 beta; Macrophage Inflammatory Protein 1 beta; MIP-1 beta; MIP-1β; Secreted protein G 26; ACT 2; ACT2; AT744.1; CC chemokine ligand 4; CCL4; ccl4l 1; CCL4L1; Chemokine CC Motif Ligand 4; G 26 T lymphocyte secreted protein; HC21; LAG 1; LAG1; Lymphocyte activation gene 1; Lymphocyte activation gene 1 protein; Macrophage inflammatory protein 1 beta; MGC104418; MGC126025; MGC126026; MIP1 beta; MIP1B; MIP1B1; PAT 744; Protein H400; SCYA2; SCYA4; Secreted protein G26; SIS gamma; Small inducible cytokine A4; T cell activation protein 2; CCL4_MOUSE; |
| 中文别名 | MIP-1β. |
| 产品应用 | IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500 Not yet tested in other applications. |
| 交叉反应 | (Human, Mouse, Rat) |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from mouse CCL4 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 7.8 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Immunology > Immune System Diseases > Antiviral Signaling > HIV-related Immunology > Innate Immunity > Chemokines > Beta Chemokines (CC) Immunology > Innate Immunity > Macrophage / Inflamm. Kits/ Lysates/ Other > Kits > ELISA Kits > ELISA Kits > Cytokines and cytokine receptors ELISA kits |
| 亚基 | Homodimer and heterodimer of MIP-1-alpha(4-69) and MIP-1-beta(3-69). |
| 亚细胞定位 | Secreted. |
| 翻译后修饰 | N-terminal processed form MIP-1-beta(3-69) is produced by proteolytic cleavage after secretion from peripheral blood lymphocytes. |
| 相似性 | Belongs to the intercrine beta (chemokine CC) family. |
| 功能 | Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | MIP1 alpha and MIP1 beta were originally co-purified from medium conditioned by an LPS-stimulated murine macrophage cell line. Human MIP1 beta refers to the products of several independently cloned cDNAs, including Act2, PAT 744, hH400, G26, HIMAP, HC21, and MAD 5a. The predicted protein products of these cDNAs represent variants that are between 94% - 98% identical and these proteins are all approximately 75% homologous to murine MIP1 beta. MIP1 beta also shares approximately 70% amino acid identity with MIP1 alpha. MIP1 proteins are expressed primarily in T cells, B cells, and monocytes after antigen or mitogen stimulation. The MIP1 proteins have chemoattractant and adhesive effects on lymphocytes, with MIP1 alpha and MIP1 beta preferentially attracting CD8+ and CD4+ T cells, respectively. A signal transducing receptor designated the CC chemokine receptor 1 (CC CKR1) with seven transmembrane domains that binds MIP1 alpha, MIP1 beta, MCP1 and RANTES with varying affinities has been isolated. |
| 应用 | 推荐稀释比例 |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {IF} | {1:100-500} |
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文献和实验[IF={{ 6.208 }}] {Hanh Hong Chu. et al. CCL4 Regulates Eosinophil Activation in Eosinophilic Airway Inflammation. INT J MOL SCI. 2022 Jan;23(24):16149} {IF} {Human}
[IF={{ 5.1 }}] {Yoshiki Kobayashi. et al. CCL4 Affects Eosinophil Survival via the Shedding of the MUC1 N-Terminal Domain in Airway Inflammation. CELLS-BASEL. 2024 Dec;14(1):33} {IF} {Human}
[IF={{ 4.4 }}] {Lee et al. Caveolin-1 regulates chemokine receptor 5-mediated contribution of bone marrow-derived cells to dermal fibrosis. (2014) Front.Pharmaco. 5:140} {IHC} {Human,Mouse,Rabbit}
[IF={{ 4.2 }}] {Hongsong Peng. et al.Identifying Therapeutic Targets and Potential Drugs for Diabetic Retinopathy: Focus on Oxidative Stress and Immune Infiltration.j inflamm res.2025 Feb 14:18:2205-2227.} {Western Blot} {Mouse}
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