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- 2026年10月13日
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50ul/100ul/200ul
| 规格： | 50ul | 产品价格： | ￥1180.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥1980.0 |
| 规格： | 200ul | 产品价格： | ￥2800.0 |
| 产品编号 | bs-0011R |
| 英文名称 | Gastrin Releasing Peptide Rabbit pAb |
| 中文名称 | 促胃泌素释放肽抗体 |
| 英文别名 | Gastrin releasing peptides; BN; Bombesin; GRP 10; GRP; GRP10; Neuromedin C; NeuromedinC; Pre progastrin releasing peptide; preproGRP; proGRP; GRP_HUMAN. |
| 产品应用 | IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500 Not yet tested in other applications. |
| 交叉反应 | Human |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human GRP |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 理论分子量 | 3/14 kDa |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cell Biology > Other Antibodies > Other Antibodies |
| 亚细胞定位 | Secreted. |
| 组织特异性 | Highly expressed both in the lateral nucleus of the amygdala, and in regions sending synaptic projections to the lateral nucleus. |
| 相似性 | ngs to the bombesin/neuromedin-B/ranatensin family. |
| 功能 | GRP stimulates gastrin release as well as other gastrointestinal hormones. Operates as a negative feedback regulating fear and established a causal relationship between GRP-receptor gene expression, long-term potentiation, and amygdala-dependent memory for fear. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a member of the bombesin-like family of gastrin-releasing peptides. The encoded preproprotein is proteolytically processed to generate two peptides, gastrin-releasing peptide and neuromedin-C. These peptides regulate numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation. These peptides are also likely to play a role in human cancers of the lung, colon, stomach, pancreas, breast, and prostate. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]. |
| 应用 | 推荐稀释比例 |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {IF} | {1:100-500} |
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文献和实验、MAMs 的生理功能。MAMs 介导 Ca²⁺稳态（A）、脂质代谢合成与运输（B）、线粒体动力学（C）、内质网应激（D）、细胞凋亡（E）、自噬（F）、铁死亡（G）以及线粒体分裂因子（Mff）炎症（H）。 1、Ca²⁺稳态：MAMs通过IP3R‒GRP75‒VDAC1复合体把ER储存的Ca²⁺精准地送进线粒体，既给线粒体提供代谢信号，又防止胞质Ca²⁺过高；当细胞需求变化时，SERCA还能把线粒体多余的Ca²⁺泵回ER，形成动态循环，这种双向调控维持了整个细胞的钙稳态。 2、 脂质合成与转运：ER
= NAL), appears to form upon oxidative cyclization of the nonfluorescent 2:1 lysine-HNE Michael adduct-Schiff base cross-link (Scheme 1). Polyclonal antibody (PAb) to the NAL-HNE fluorophore was raised in rabbit and found to be highly specific
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