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Perilipin A Rabbit pAb(bs-3789

R)-50ul/100ul/200ul
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  • ￥1180 - 2800
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  • bs-3789R
  • 2025年10月24日
  • 产品信息以Bioss网站为准
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北京博奥森生物技术有限公司
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      50ul/100ul/200ul

    规格：50ul产品价格：￥1180.0
    规格：100ul产品价格：￥1980.0
    规格：200ul产品价格：￥2800.0
    产品编号bs-3789R
    英文名称Perilipin A Rabbit pAb
    中文名称脂滴包被蛋白Perilipin-A抗体
    英文别名Lipid droplet associated protein; Lipid droplet-associated protein; PERI; Perilipin; Perilipin-1; Perilipin 1; PerilipinA; Perilipin-A; PLIN; PLIN1; PLIN1_HUMAN.
    产品应用WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应Human, Mouse, Rat (Dog, Pig, Cow, Horse, Sheep)
    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human Perilipin-1
    亚型IgG
    性状Liquid
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    理论分子量57 kDa
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cancer > Cancer Metabolism > Metabolic signaling pathway > Metabolism of lipids and lipoproteins

    Cardiovascular > Atherosclerosis > Lipoprotein metabolism

    Cardiovascular > Lipids / Lipoproteins > Adipose Related > Lipid Droplet Protein

    Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Lipid metabolism

    Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Lipoprotein metabolism

    Metabolism > Types of disease > Heart disease

    Signal Transduction > Metabolism > Lipid metabolism

    亚基Interacts with ABHD5.
    亚细胞定位Lipid droplet. Note=Lipid droplet surface-associated.
    组织特异性Adipocytes.
    翻译后修饰Major cAMP-dependent protein kinase-substrate in adipocytes, also dephosphorylated by PP1. When phosphorylated, may be maximally sensitive to HSL and when unphosphorylated, may play a role in the inhibition of lipolysis, by acting as a barrier in lipid droplet.
    相似性Belongs to the perilipin family.
    功能Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Perilipins, members of the PAT protein family (named after lipid droplet proteins Perilipin, Adipophilin, and TIP47) are found exclusively at the surface of lipid droplets in adipocytes and steroidogenic cells. They have been suggested to function as regulators of lipolysis and triacylglycerol storage within adipose tissue. Four distinct isoforms ranging from perilipin A (57 kDa) to perilipin D (26 kDa) have been identified and they share an identical amino terminal sequences, and contain 2–6 consensus protein kinase A (PKA) phosphorylation sites. Perilipin C and D have been detected only in steroidogenic cells. Perilipin A is the most abundant form on the lipid droplets of adipocytes. The phosphorylation of perilipin by PKA, which is accompanied by the phosphorylation and translocation of hormone-sensitive lipase from the cytosol to the lipid droplets, promotes lipolysis. There is evidence for the presence of perilipin A in atheroma plaques suggesting that the protein may be involved in the development of therosclerosis by controlling as in adipocytes the hydrolysis of stored lipids.

     

    应用推荐稀释比例
    {WB}{1:500-2000}
    {IHC-P}{1:100-500}
    {IHC-F}{1:100-500}
    {IF}{1:100-500}

     

    产品细节图片1
    Sample:Parotid gland (Mouse) Lysate at 40 ug
    Primary: Anti-Perilipin A (bs-3789R) at 1/300 dilution
    Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    Predicted band size: 57 kD
    Observed band size: 57 kD
    产品细节图片2
    Sample: Thymus (Mouse) Lysate at 40 ug
    Primary: Anti-Perilipin A (bs-3789R) at 1/300 dilution
    Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    Predicted band size: 57 kD
    Observed band size: 57 kD
    产品细节图片3
    P‌‌araformaldehyde-fixed, paraffin embedded (rat ovary); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Perilipin A ) Polyclonal Antibody, Unconjugated (bs-3789R) at 1:400 overnight at 4°C, followed by a conjugated secondary antibody (sp-0023) for 20 minutes and DAB staining.
    产品细节图片4
    Sample:
    MCF-7 Cell (Human) Lysate at 30 ug
    Primary: Anti-Perilipin A (Bs- 3789R) at 1/300 dilution
    Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    Predicted band size: 57 kD
    Observed band size: 57 kD

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    图标文献和实验
    该产品被引用文献

    [IF={{ 5.9 }}] {Cheng Yun-Mou. et al. An immortal porcine preadipocyte cell strain for efficient production of cell-cultured fat. COMMUN BIOL. 2023 Nov;6(1):1-13} {WB} {Pig}

    [IF={{ 4.05 }}] {Stelmanska, Ewa, Sylwia Szrok, and Julian Swierczynski. "Progesterone induced down regulation of hormone sensitive lipase ( Lipe) and up-regulation of G0/G1 switch 2 (G0s2) genes expression in inguinal adipose tissue of female rats is reflected by diminished rate of lipolysis." The Journal of Steroid Biochemistry and Molecular Biology (2014).} {WB} {="Rat"}

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    文献支持
    Perilipin A Rabbit pAb(bs-3789R)-50ul/100ul/200ul
    ￥1180 - 2800