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NES/Kallikrein 10 Rabbit pAb(b

s-2531R)-50ul/100ul/200ul
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  • ￥1180 - 2800
  • Bioss已认证
  • bs-2531R
  • 2025年10月16日
  • 产品信息以Bioss网站为准
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      50ul/100ul/200ul

    规格：50ul产品价格：￥1180.0
    规格：100ul产品价格：￥1980.0
    规格：200ul产品价格：￥2800.0
    产品编号bs-2531R
    英文名称NES/Kallikrein 10 Rabbit pAb
    中文名称上皮细胞特异性蛋白1抗体
    英文别名Kallikrein 10; Breast normal epithelial cell associated serine protease; Kallikrein related peptidase 10; KLK 10; KLK10; KLK10_HUMAN; NES 1; NES1; Normal epithelial cell specific 1; Protease serine like 1; PRSS L1; PRSSL 1; PRSSL1.
    产品应用WB=1:500-2000

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应Human (Mouse, Rat, Cow)
    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human KLK10
    亚型IgG
    性状Liquid
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    理论分子量31 kDa
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    亚细胞定位Secreted.
    组织特异性Expressed in breast, ovary and prostate.
    相似性Belongs to the peptidase S1 family. Kallikrein subfamily.
    Contains 1 peptidase S1 domain.
    功能Has a tumor-suppressor role for NES1 in breast and prostate cancer.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Kallikrein 10 is a trypsin-like serine proteinase. Originally described from a subtractive library looking for genes that were down-regulated in breast cancer, kallikrein 10 was thought to be epithelial cell specific. Kallikrein 10 is reported to be up regulated in pancreatic cancer and ovarian cancer, but down regulated in testicular cancer and breast cancer, perhaps due to differential hormonal regulation, or tissue specificities. Breast cancer patients that had elevated kallikrein 10 had a worse prognosis, leading to speculation that kallikrein 10 might be protective in breast cancer, similar to the argument put forth for kallikrein 3 in prostate cancer. Kallikrein 10 is found in high levels in the pancreas and in lower levels in the tonsils, esophagus, skin, brain, testis and ovary. Biological fluids (breast milk, serum, seminal plasma, urine) contain kallikrein 10, the highest levels found in milk. The cerebral spinal fluid (CSF) contains Kallikrein 10, and was reported to be elevated in patients with Alzheimer’s disease. Endogenous inhibitors include kallistatin, protein-C inhibitor and 1-proteinase inhibitor, although Kallikrein 10 can be found complexed to a number of different proteinase inhibitors.

     

    应用推荐稀释比例
    {WB}{1:500-2000}

     

    产品细节图片1
    Sample:
    MCF-7(Human) Cell Lysate at 30 ug
    Primary: Anti-NES/Kallikrein 10 (bs-2531R) at 1/300 dilution
    Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    Predicted band size: 31 kD
    Observed band size: 31 kD
    产品细节图片2
    Sample:
    DU145(Human) Cell Lysate at 30 ug
    Primary: Anti-NES/Kallikrein 10 (bs-2531R) at 1/300 dilution
    Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
    Predicted band size: 31 kD
    Observed band size: 31 kD

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    图标文献和实验
    该产品被引用文献

    [IF={{ 3.7 }}] {Wei Cheng. et al. LRG1 promotes the apoptosis of pulmonary microvascular endothelial cells through KLK10 in chronic obstructive pulmonary disease. TOB INDUC DIS. 2024; 22: 10.18332/tid/186404} {IHC,IF,WB} {Human,Mouse}

    [IF={{ 2.559 }}] {Cao XY et al. Aberrant upregulation of KLK10 promotes metastasis via enhancement of EMT and FAK/SRC/ERK axis in PDAC.Biochem Biophys Res Commun. 2018 May 15;499(3):584-593.} {IHC,WB} {Mouse&Human}

    [IF={{ 2.3 }}] {Li, Lei, et al. "Upregulated KLK10 inhibits esophageal cancer proliferation and enhances cisplatin sensitivity in vitro." Oncology Reports.} {WB} {=""}

    [IF={{ 0 }}] {Wang et al. Chemoprevention activity of dipyridamole in the MMTV-PyMT transgenic mouse model of breast cancer. (2013) Cancer.Prev.Res.(Phila. 6:437-47} {WB} {Human}

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    文献支持
    NES/Kallikrein 10 Rabbit pAb(bs-2531R)-50ul/100ul/200ul
    ￥1180 - 2800